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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Microspheres from new biodegradable poly(ester amide)s with different ratios of L- and D-alanine for controlled drug delivery
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Microspheres from new biodegradable poly(ester amide)s with different ratios of L- and D-alanine for controlled drug delivery

机译：来自新型可生物降解的聚（酯酰胺）的微球，具有不同比例的L-和D-丙氨酸以控制药物的输送

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摘要

A series of biodegradable poly (ester amide) s composed of sebacic acid, dodecanediol and different ratios of the stereoisomers of L- and D-alanine were synthesized for applications in drug delivery systems. Microspheres loaded with diclofenac sodium salt, triclosan and clofazimine were prepared with the solvent evaporation technique. No influence of polymer constitution in the drug release rate was found in vitro and no degradation occurred during the period of drug release. It was shown that a sustained delivery of the hydrophilic diclofenac sodium salt in Sorensen media occurred and it was controlled by diffusion. However, exhaustion of microspheres was feasible only from the most porous matrices where channelling had an important contribution.
机译：合成了由癸二酸，十二烷二醇和不同比例的L-和D-丙氨酸的立体异构体组成的一系列可生物降解的聚（酯酰胺），用于药物递送系统。用溶剂蒸发技术制备了载有双氯芬酸钠盐，三氯生和氯氟齐明的微球。在体外未发现聚合物组成对药物释放速率的影响，并且在药物释放期间未发生降解。结果表明，亲水性双氯芬酸钠盐在Sorensen培养基中持续释放，并受扩散控制。但是，仅从大多数多孔基质中排出微球才是可行的，在这些基质中，通道作用起着重要作用。

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