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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Tabletted microspheres containing Cynara scolymus (var.Spinoso sardo) extract for the preparation of controlled release nutraceutical matrices
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Tabletted microspheres containing Cynara scolymus (var.Spinoso sardo) extract for the preparation of controlled release nutraceutical matrices

机译：含有粘多糖（Cynara scolymus）（斯皮诺索·萨多变种）提取物的片剂化微球，用于制备控释保健食品基质

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Controlled release dosage forms based on tabletted microspheres containing fresh artichoke Cynara scolymus extract were performed for the oral administration of a nutritional supplement.Microspheres were prepared using a spray-drying technique;lactose or hypromellose have been chosen as excipients.Microspheres were characterized in terms of encapsulated extract content,size and morphology.Qualitative and quantitative composition of the extract before and after the spray process was determined.Compressed matrices (tablets) were prepared by direct compression of the spray-dried microspheres.In vitro release tests of microparticles and tablets prepared were carried out in both acidic and neutral media.Spray-drying is a good method to prepare micro-spheres containing the artichoke extract.The microspheres encapsulate an amount of extract close to the theoretical value.Particle size analyses indicate that the microparticles have dvs of approx 6-7 mu m.Electronic microscopy observations reveal that particles based on lactose have spherical shape and particles containing hypromellose are almost collapsed.The hydroalcoholic extract is stable to the microsphere production process:its polyphenolic composition (qualitative and quantitative) did not change after spraying.In vitro release studies show that microparticles characterized by a quick polyphenolic release both in acidic and neutral media due to the high water solubility of the carrier lactose.On the contrary,microspheres based hypromellose release only 20% of the loaded extract at pH 1.2 in 2 h and the total amount of polyphenols is released only after about further 6 h at pH 6.8.Matrices prepared tabletting lactose microspheres and hypromellose microparticles in the weight ratio 1:1 show a slow release rate,that lasts approx 24 h.This one-a-day sustained release formulation containing Cynara scolymus extract could be proposed as a nutraceutical controlled release dosage form for oral administration.
机译：以含有新鲜朝鲜蓟Cynara scolymus提取物的压片微球为基础的控释剂型，用于口服营养补充剂;采用喷雾干燥技术制备微球;选择乳糖或羟丙甲纤维素为赋形剂。包被的提取物的含量，大小和形态。在喷雾过程之前和之后确定提取物的定性和定量组成。通过直接压缩喷雾干燥的微球制备压缩基质（片剂）。制备的微粒和片剂的体外释放试验喷雾干燥是制备含朝鲜蓟提取物的微球的一种好方法。微球包封了一定量的提取物，接近理论值。颗粒大小分析表明该微粒具有dvs。约6-7微米电镜观察结果表明，基于乳糖的颗粒呈球形，含有羟丙甲纤维素的颗粒几乎崩溃了。该水醇提取物对微球的生产过程稳定：喷雾后其多酚组成（定性和定量）不变。由于载体乳糖的高水溶性，可在酸性和中性介质中迅速释放多酚。相反，基于微球的羟丙甲纤维素在2小时内在pH 1.2下仅释放20％的负载提取物，而多酚的总量为仅在pH 6.8下约6 h后才释放。制备的片剂以重量比1：1压制乳糖微球和羟丙甲纤维素微粒显示出缓慢的释放速率，持续约24 h。这种含有Cynara scolymus的一日持续释放制剂提取物可以被提议为口服给药的营养保健控释剂型。

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