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首页> 外文期刊>Journal of nephrology. >Effective treatment administration of cyclophosphamide in membranous nephropathy.
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Effective treatment administration of cyclophosphamide in membranous nephropathy.

机译：膜性肾病中环磷酰胺的有效治疗。

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BACKGROUND: Idiopathic membranous nephropathy (IMN) is the most common cause of nephrotic syndrome in adults. In this prospective study, we investigated the efficacy of combined use of oral or pulse cyclophosphamide (CYC) with low-dose steroid on our group of adult IMN patients whose renal function was normal at the time of diagnosis. METHODS: The study was performed on 33 adult patients who had not previously been treated with immunosuppressive agents. All patients were treated with prednisone (0.5 mg/kg per day) for 1 year. In addition to this treatment, oral CYC (1.5-2 mg/kg per day) and pulse CYC (500 mg/m2 per month) were administered for 6 months to 17 and 16 patients, respectively. RESULTS: At the end of the follow-up period, serum creatinine levels were either decreased or had remained stable in both groups. Daily protein excretion was improved in all but 3 patients. Complete or partial remission was achieved in 9 and 10 of 33 patients, respectively. Serum albumin levels were significantly increased in both groups (p=0.027). These levels were higher in the pulse CYC group than in the oral CYC group, and the difference between the 2 groups was statistically significant. CONCLUSIONS: With regard to patients with IMN, the combination of CYC with corticosteroids was beneficial in conserving renal function and in induction of remission of nephrotic syndrome. We observed that pulse CYC treatment significantly increased serum albumin levels when compared with oral CYC.
机译：背景：特发性膜性肾病（IMN）是成人肾病综合征最常见的病因。在这项前瞻性研究中，我们调查了口服或脉冲环磷酰胺（CYC）与低剂量类固醇联合使用对我们诊断为肾功能正常的成年IMN患者的疗效。方法：该研究是针对33名未曾接受免疫抑制剂治疗的成年患者进行的。所有患者均接受泼尼松（每天0.5 mg / kg）治疗1年。除此治疗外，还分别对17位和16位患者进行了6个月的口服CYC（每天1.5-2 mg / kg）和脉搏CYC（每月500 mg / m2）给药。结果：在随访期结束时，两组的肌酐水平均下降或保持稳定。除3名患者外，其他所有患者的每日蛋白质排泄均得到改善。 33例患者中有9例和10例完全或部分缓解。两组血清白蛋白水平均显着升高（p = 0.027）。脉冲CYC组的这些水平高于口服CYC组，并且两组之间的差异具有统计学意义。结论：对于IMN患者，CYC与皮质类固醇的联合治疗有益于保存肾功能和诱导肾病综合征的缓解。我们观察到，与口服CYC相比，脉冲CYC治疗显着增加了血清白蛋白水平。

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