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首页> 外文期刊>Journal of nephrology. >Is morning urinary protein/creatinine ratio a reliable estimator of 24-hour proteinuria in patients with glomerulonephritis and different levels of renal function?
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Is morning urinary protein/creatinine ratio a reliable estimator of 24-hour proteinuria in patients with glomerulonephritis and different levels of renal function?

机译：肾小球肾炎和肾功能不同水平的患者，晨尿蛋白/肌酐比值是否是24小时蛋白尿的可靠估计值？

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BACKGROUND: This cross-sectional study was conducted to determine whether a spot urine protein/creatinine ratio (UPr/UCr) provides accurate quantitation of 24-hr urinary protein excretion (24-hr Prot) in out-patients with primary glomerulonephritis (GN) and different renal function levels. METHODS: Patients were classified into three groups according to creatinine (Cr) clearance (ml/min) and into five categories according to morning UPr/UCr. Correlation between 24-hr Prot and UPr/UCr was calculated according to the three renal function levels. The Bland and Altman method was used to assess agreement between 24-hr Prot and UPr/UCr. Agreement limits were obtained calculating the mean difference between 24-hr Prot and morning UPr/UCr +/- 2SD. Sensitivity and specificity were determined for different renal function levels and UPr/UCr cut-off values. RESULTS: High correlation coefficients (r=0.91, 0.95 and 0.98) were observed in patients with normal, reduced and severely reduced renal function. Differences and variability between 24-hr Prot and UPr/UCr tended to increase with higher proteinuria levels, and this trend was observed for the three renal function levels. The best UPr/UCrcut-off values to detect abnormal or nephrotic proteinuria were, respectively, 0.3 and 2.6. CONCLUSIONS: Correlation and agreement between UPr/UCr and 24-hr Prot was good for all renal function levels, but demonstrated more marked differences as urinary protein excretion increased. Morning UPr/UCr had good sensitivity and specificity for the diagnosis of 24-hr Prot, even in patients with reduced renal function.
机译：背景：这项横断面研究旨在确定门诊原发性肾小球肾炎（GN）患者尿蛋白/肌酐比值（UPr / UCr）是否能准确定量24小时尿蛋白排泄（24小时Prot）。和不同的肾功能水平。方法：根据肌酐（Cr）清除率（ml / min）将患者分为三类，根据早晨UPr / UCr分为五类。根据三个肾功能水平计算24小时Prot与UPr / UCr之间的相关性。使用Bland和Altman方法评估24小时Prot与UPr / UCr之间的一致性。通过计算24小时Prot与早晨UPr / UCr +/- 2SD之间的平均差异来获得协议限制。确定了不同肾功能水平和UPr / UCr临界值的敏感性和特异性。结果：在肾功能正常，降低和严重降低的患者中观察到高相关系数（r = 0.91、0.95和0.98）。蛋白尿水平较高时，24小时Prot与UPr / UCr之间的差异和变异性趋于增加，并且在三种肾功能水平中均观察到这种趋势。检测异常或肾病蛋白尿的最佳UPr / UCrcut-off值分别为0.3和2.6。结论：UPr / UCr与24小时Prot之间的相关性和一致性对所有肾功能水平均良好，但随着尿蛋白排泄量增加，表现出更明显的差异。早晨UPr / UCr对24小时Prot的诊断具有良好的敏感性和特异性，即使在肾功能下降的患者中也是如此。

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