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首页> 外文期刊>Journal of nephrology. >Characterization of renal hemodynamic and structural alterations in rat models of renal impairment: role of renal sympathoexcitation.
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Characterization of renal hemodynamic and structural alterations in rat models of renal impairment: role of renal sympathoexcitation.

机译：肾功能不全大鼠模型中肾脏血液动力学和结构改变的特征：肾交感神经兴奋的作用。

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BACKGROUND: Renal sympathetic innervation plays an important role in the control of renal hemodynamics and may therefore contribute to the pathophysiology of many disease states affecting the kidney. Thus, the present study aimed to investigate the role of the renal sympathetic nervous system in the early deteriorations of renal hemodynamics and structure in rats with pathophysiological states of renal impairment. METHODS: Anesthetized Sprague Dawley (SD) rats with cisplatin-induced acute renal failure (ARF) or streptozotocin (STZ)-induced diabetes mellitus (DM) were subjected to a renal hemodynamic study 7 days after cisplatin and STZ administration. During the acute study, renal nerves were electrically stimulated, and responses in renal blood flow (RBF) and renal vascular resistance (RVR) were recorded in the presence and absence of renal denervation. Post mortem kidney collection was performed for histopathological assessment. RESULTS: In innervated ARF or DM rats, renal nerve stimulation produced significantly lower (all p<0.05, vs. innervated control) renal vasoconstrictor responses. These responses were markedly abolished when renal denervation was performed (all p<0.05); however, they appeared significantly higher compared with denervated controls (all p<0.05). Kidney injury was suppressed in denervated ARF, while, irrespective of renal denervation, renal specimens from DM rats were comparable to controls. CONCLUSIONS: Renal sympathoexcitation is involved in the pathogenesis of the renal impairment accompanying ARF and DM, and may even precede the establishment of an observable renal injury. There is a possible enhancement in the renal sensitivity to intrarenal norepinephrine following renal denervation in ARF and DM rats.
机译：背景：肾脏交感神经支配在控制肾脏血液动力学中起着重要作用，因此可能有助于影响肾脏的许多疾病状态的病理生理。因此，本研究旨在探讨肾交感神经系统在具有肾功能不全的病理生理状态的大鼠肾血液动力学和结构的早期恶化中的作用。方法：麻醉的顺铂诱导的急性肾衰竭（ARF）或链脲佐菌素（STZ）诱导的糖尿病（DM）的Sprague Dawley（SD）大鼠在顺铂和STZ给药后7天接受肾脏血液动力学研究。在急性研究期间，对肾神经进行电刺激，并在有和无肾去神经支配的情况下记录肾血流量（RBF）和肾血管阻力（RVR）的反应。进行死后肾脏收集以进行组织病理学评估。结果：在神经支配的ARF或DM大鼠中，肾神经刺激产生的肾血管收缩反应明显降低（相对于神经支配对照组，所有p <0.05）。进行肾神经支配时，这些反应明显消失（所有p <0.05）;然而，与失神经的对照组相比，它们显得明显更高（所有p <0.05）。失神经的ARF可抑制肾脏损伤，而与肾脏失神经无关，DM大鼠的肾脏标本与对照组相当。结论：肾交感神经兴奋与ARF和DM伴随的肾功能损害的发病机制有关，甚至可能在建立可观察到的肾损伤之前发生。肾去神经支配后，ARF和DM大鼠肾脏对肾内去甲肾上腺素的敏感性可能增强。

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