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首页> 外文期刊>Journal of Neurophysiology >Combined unilateral lesions of the amygdala and orbital prefrontal cortex impair affective processing in rhesus monkeys.
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Combined unilateral lesions of the amygdala and orbital prefrontal cortex impair affective processing in rhesus monkeys.

机译：杏仁核和眶前额叶皮层的单侧合并损害损害了恒河猴的情感加工。

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摘要

The amygdala and orbital prefrontal cortex (PFo) interact as part of a system for affective processing. To assess whether there is a hemispheric functional specialization for the processing of emotion or reward or both in nonhuman primates, rhesus monkeys (Macaca mulatta) with combined lesions of the amygdala and PFo in one hemisphere, either left or right, were compared with unoperated controls on a battery of tasks that tax affective processing, including two tasks that tax reward processing and two that assess emotional reactions. Although the two operated groups did not differ from each other, monkeys with unilateral lesions, left and right, showed altered reward-processing abilities as evidenced by attenuated reinforcer devaluation effects and an impairment in object reversal learning relative to controls. In addition, both operated groups showed blunted emotional reactions to a rubber snake. By contrast, monkeys with unilateral lesions did not differ from controls in their responses to an unfamiliar human (human "intruder"). Although the results provide no support for a hemispheric specialization of function, they yield the novel finding that unilateral lesions of the amygdala-orbitofrontal cortical circuit in monkeys are sufficient to significantly disrupt affective processing.
机译：杏仁核和眶前额叶皮层（PFo）作为情感处理系统的一部分进行交互。为了评估在非人类灵长类动物中是否存在半球形的功能专长，用于处理情感或奖赏或二者兼有，将在一个或半个左右半球带有杏仁核和PFo合并病变的恒河猴（猕猴）与未操作的对照组进行比较涉及情感处理的一系列任务，包括两项奖励处理的任务和两项评估情感反应的任务。尽管两个手术组没有区别，但左右两侧有单侧病变的猴子表现出改变的奖赏处理能力，这是由于强化物贬值作用减弱和相对于对照的对象逆向学习障碍所证明的。此外，两个手术组对橡皮蛇的情绪反应均减弱。相比之下，具有单侧损伤的猴子对陌生人（人类“入侵者”）的反应与对照组没有差异。尽管结果不支持半球功能的特殊性，但他们得出了新发现：猴子杏仁核-眶额皮质回路的单侧损害足以显着破坏情感加工。

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