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首页> 外文期刊>Journal of Neurophysiology >Hair-cell versus afferent adaptation in the semicircular canals.
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Hair-cell versus afferent adaptation in the semicircular canals.

机译：半圆形管中的毛细胞与传入适应。

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摘要

The time course and extent of adaptation in semicircular canal hair cells was compared to adaptation in primary afferent neurons for physiological stimuli in vivo to study the origins of the neural code transmitted to the brain. The oyster toadfish, Opsanus tau, was used as the experimental model. Afferent firing-rate adaptation followed a double-exponential time course in response to step cupula displacements. The dominant adaptation time constant varied considerably among afferent fibers and spanned six orders of magnitude for the population ( approximately 1 ms to >1,000 s). For sinusoidal stimuli (0.1-20 Hz), the rapidly adapting afferents exhibited a 90 degrees phase lead and frequency-dependent gain, whereas slowly adapting afferents exhibited a flat gain and no phase lead. Hair-cell voltage and current modulations were similar to the slowly adapting afferents and exhibited a relatively flat gain with very little phase lead over the physiological bandwidth and dynamic range tested. Semicircular canal microphonics also showed responses consistent with the slowly adapting subset of afferents and with hair cells. The relatively broad diversity of afferent adaptation time constants and frequency-dependent discharge modulations relative to hair-cell voltage implicate a subsequent site of adaptation that plays a major role in further shaping the temporal characteristics of semicircular canal afferent neural signals.
机译：将半圆形管毛细胞的适应性时程和程度与原发传入神经元对体内生理刺激的适应性进行比较，以研究传递至大脑的神经密码的起源。牡蛎蟾蜍鱼（Opsanus tau）被用作实验模型。传入的发射速率适应遵循双指数时间过程，以响应阶梯形吸盘位移。传入纤维之间的主要适应时间常数变化很大，并且整个种群跨越了六个数量级（大约1毫秒至> 1,000 s）。对于正弦刺激（0.1-20 Hz），快速适应的传入显示出90度的相位超前和频率相关的增益，而缓慢适应的传入显示出平坦的增益且无相位超前。毛细胞的电压和电流调制与缓慢适应的传入细胞相似，并且在测试的生理带宽和动态范围内，显示出相对平坦的增益，几乎没有相位超前。半圆管微音学还显示出与缓慢适应的传入子集和毛细胞一致的响应。传入适应时间常数和频率相关的放电调制相对于毛细胞电压的相对广泛的多样性暗示着后续的适应位点，该位点在进一步塑造半规管传入神经信号的时间特性中起着重要作用。

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