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首页> 外文期刊>Journal of Neurophysiology >Spike-timing precision underlies the coding efficiency of auditory receptor neurons.
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Spike-timing precision underlies the coding efficiency of auditory receptor neurons.

机译：计时准确度是听觉受体神经元编码效率的基础。

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摘要

Sensory systems must translate incoming signals quickly and reliably so that an animal can act successfully in its environment. Even at the level of receptor neurons, however, functional aspects of the sensory encoding process are not yet fully understood. Specifically, this concerns the question how stimulus features and neural response characteristics lead to an efficient transmission of sensory information. To address this issue, we have recorded and analyzed spike trains from grasshopper auditory receptors, while systematically varying the stimulus statistics. The stimulus variations profoundly influenced the efficiency of neural encoding. This influence was largely attributable to the presence of specific stimulus features that triggered remarkably precise spikes whose trial-to-trial timing variability was as low as 0.15 ms--one order of magnitude shorter than typical stimulus time scales. Precise spikes decreased the noise entropy of the spike trains, thereby increasing the rate of information transmission. In contrast, the total spike train entropy, which quantifies the variety of different spike train patterns, hardly changed when stimulus conditions were altered, as long as the neural firing rate remained the same. This finding shows that stimulus distributions that were transmitted with high information rates did not invoke additional response patterns, but instead displayed exceptional temporal precision in their neural representation. The acoustic stimuli that led to the highest information rates and smallest spike-time jitter feature pronounced sound-pressure deflections lasting for 2-3 ms. These upstrokes are reminiscent of salient structures found in natural grasshopper communication signals, suggesting that precise spikes selectively encode particularly important aspects of the natural stimulus environment.
机译：感觉系统必须快速，可靠地转换输入信号，以便动物可以在其环境中成功采取行动。然而，即使在受体神经元的水平上，感觉编码过程的功能方面仍未完全理解。特别地，这涉及到刺激特征和神经反应特征如何导致感官信息的有效传递的问题。为了解决这个问题，我们记录并分析了来自蚱hopper听觉感受器的尖峰序列，同时系统地改变了刺激统计数据。刺激变化深刻地影响了神经编码的效率。这种影响在很大程度上归因于特定刺激特征的存在，这些特征触发了非常精确的尖峰，其试验到试验的时间变异性低至0.15毫秒-比典型刺激时间尺度短一个数量级。精确的尖峰降低了尖峰序列的噪声熵，从而提高了信息传输的速率。相反，只要刺激条件不变，总的峰值序列熵就可以量化变化的峰值序列模式的多样性，而当刺激条件改变时，熵几乎不变。该发现表明，以高信息速率传输的刺激分布不会调用其他响应模式，而是在神经表示中显示出非凡的时间精度。导致最高信息速率和最小尖峰时间抖动的声学刺激具有明显的声压偏转，持续2-3 ms。这些上升使人联想到天然蝗虫通讯信号中的显着结构，这表明精确的尖峰选择性地编码了自然刺激环境中特别重要的方面。

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