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首页> 外文期刊>Journal of Neurophysiology >Feedforward inhibitory connections from multiple thalamic cells to multiple regular-spiking cells in layer 4 of the somatosensory cortex.
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Feedforward inhibitory connections from multiple thalamic cells to multiple regular-spiking cells in layer 4 of the somatosensory cortex.

机译：在体感皮层的第4层中，从多个丘脑细胞到多个规则加标细胞的前馈抑制性连接。

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摘要

Thalamocortical (TC) cells in the ventrobasal thalamus make direct excitatory connections with regular-spiking (RS) cells in layer 4 of the somatosensory cortex, but also make disynaptic feedforward inhibitory connections with the RS cells by layer 4 fast-spiking (FS) cells. In this study, we investigated connection rules of the feedforward inhibitory circuit from multiple TC cells to multiple RS cells, at the level of synaptic potentials. Using thalamocortical brain slices of young mice (postnatal days 12-16), we made simultaneous patch-clamp recordings from three adjacent cortical cells (two RS cells and one FS cell), combined with minimal stimulation of presumed single TC fibers. We found that nearly all (97%) of TC fibers, which generated excitatory inputs onto RS cells, also generated divergent excitatory inputs onto adjacent FS cells. Some 44% of TC fibers generated divergent excitatory inputs onto adjacent pairs of RS cells. We then combined the triple patch-clamp recording with multisite (two to three) minimal stimulation of single TC fibers and found that 86% of FS cells received convergent inputs from all of the stimulated TC fibers. We also found that 68% of FS cells generated divergent inhibitory inputs onto adjacent pairs of RS cells. The results indicate that spikes in TC cells, which excite RS cells, also excite adjacent FS cells with high fidelity. The results also indicate that FS cells receive convergent excitatory inputs from multiple TC cells and then send divergent inhibitory outputs to multiple RS cells.
机译：腹侧丘脑中的丘脑皮质（TC）细胞与体感皮质第4层中的常规加味（RS）细胞建立直接兴奋性连接，但第4层快速加味（FS）细胞与RS细胞形成突触前馈抑制性连接。在这项研究中，我们研究了在突触电位水平下从多个TC细胞到多个RS细胞的前馈抑制电路的连接规则。使用幼鼠的丘脑皮质切片（出生后12-16天），我们从三个相邻的皮质细胞（两个RS细胞和一个FS细胞）同时进行膜片钳记录，并结合了对假定的单个TC纤维的最小刺激。我们发现几乎所有（97％）的TC纤维在RS细胞上产生了兴奋性输入，在邻近的FS细胞上也产生了不同的兴奋性输入。大约44％的TC纤维在相邻的RS细胞对上产生了不同的兴奋性输入。然后，我们将三重膜片钳记录与单个TC纤维的多部位（两到三个）最小刺激相结合，发现86％的FS细胞从所有受刺激的TC纤维接收会聚的输入。我们还发现68％的FS细胞在相邻的RS细胞对上产生了不同的抑制性输入。结果表明，激发RS细胞的TC细胞中的尖峰也以高保真度激发相邻的FS细胞。结果还表明，FS细胞从多个TC细胞接收会聚的兴奋性输入，然后向多个RS细胞发送发散的抑制性输出。

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