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首页> 外文期刊>Journal of Neurophysiology >Effect of benzodiazepine hypnotic triazolam on relationship of blood pressure and Paco2 to cerebral blood flow during human non-rapid eye movement sleep.
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Effect of benzodiazepine hypnotic triazolam on relationship of blood pressure and Paco2 to cerebral blood flow during human non-rapid eye movement sleep.

机译：苯二氮卓催眠三唑仑对人非快速眼动睡眠中血压和Paco2与脑血流的关系的影响。

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We sought to clarify the effect of short-acting benzodiazepine hypnotic on the relationship of arterial blood pressure and arterial partial pressure of carbon dioxide (Paco2) to regional cerebral blood flow (rCBF) during human non-rapid-eye-movement (non-REM) sleep. Nine young normal volunteers were treated in a randomized, crossover design with triazolam or placebo and underwent positron emission tomography at night. During wakefulness and stage 2 and slow wave (stages 3 and 4) sleep, we measured mean arterial blood pressure (MAP), Paco2, and absolute CBF. With triazolam compared to placebo, MAP reduced gradually. During stage 2 sleep, Paco2 increased and whole-brain mean CBF decreased. With triazolam, relative rCBF of the left orbital basal forebrain decreased more during stage 2 than slow wave sleep, whereas absolute CBF of the occipital cortex and cerebral white matter remained constant. During triazolam-induced stage 2 sleep, absolute CBF of the cerebral white matter correlated more strongly to both MAP and Paco2 than during placebo sleep and also correlated more strongly to both MAP and Paco2 than absolute CBF of the occipital cortex. In the frontal white matter, during triazolam-induced stage 2 sleep compared to wakefulness, absolute CBF was significantly better correlated to MAP, but not to Paco2. During triazolam-induced stage 2, the cerebral white matter may receive a modulated CBF regulation having the strengthened relationship of Paco2 to CBF and, more locally, the frontal white matter may depend precariously on CBF regulation.
机译：我们试图阐明短效苯二氮卓类催眠药对人非快速眼动（non-REM）过程中动脉血压和二氧化碳（Paco2）与局部脑血流量（rCBF）的关系。 ）睡觉。 9名年轻的正常志愿者接受了三唑仑或安慰剂的随机，交叉设计治疗，并在晚上进行了正电子发射断层扫描。在清醒和第2阶段以及慢波（第3和第4阶段）睡眠期间，我们测量了平均动脉血压（MAP），Paco2和绝对CBF。与安慰剂相比，三唑仑的MAP逐渐降低。在第2阶段的睡眠中，Paco2升高，全脑平均CBF降低。对于三唑仑，在第2阶段，左眼眶基底前脑的相对rCBF下降比慢波睡眠下降更多，而枕皮质和脑白质的绝对CBF保持恒定。在三唑仑诱导的2期睡眠中，与安慰剂睡眠相比，脑白质的绝对CBF与MAP和Paco2的相关性更强，并且与枕叶的绝对CBF的相关性也与MAP和Paco2的相关性更强。在额叶白质中，在三唑仑诱导的第2阶段睡眠中，与清醒相比，绝对CBF与MAP的相关性更好，但与Paco2的相关性更好。在三唑仑诱导的阶段2中，脑白质可能会受到调节的CBF调节，其Paco2与CBF的关系增强，而额叶白质可能更不稳定地依赖于CBF调节。

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