...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neurophysiology >Neuronal firing before and after burst discharges in the monkey basal ganglia is predictably patterned in the normal state and altered in parkinsonism.
【24h】

Neuronal firing before and after burst discharges in the monkey basal ganglia is predictably patterned in the normal state and altered in parkinsonism.

机译：在正常状态下，猴子基底神经节突放电前后的神经元放电可预见在正常状态下会发生变化，并在帕金森氏症中发生改变。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

It is known that burst discharges in basal ganglia neurons are more common in parkinsonism than under normal conditions, but changes in the structure of burst or peri-burst epochs have not been reported. In this study, the temporal structure of bursts and the timing of neuronal discharges that precede or follow them were examined in neuronal spike trains recorded in the subthalamic nucleus (STN) and the external and internal pallidal segment (GPe, GPi) in two awake Rhesus monkeys before and after they were rendered hemiparkinsonian by unilateral intracarotid infusion of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Bursts were detected by the "surprise" method. In the normal state, interspike intervals (ISIs) preceding or following bursts were frequently significantly longer than the average baseline ISI, and their duration was correlated with the burst length (i.e., the number of spikes/burst). Significant correlations were also found in all three structures between the burst length and the duration of interburst intervals. The incidence of burst discharges and the proportion of time spent in bursts increased in GPe, STN, and GPi after MPTP treatment. Burst lengths became more tightly related to preburst ISIs in the STN after MPTP treatment and to postburst ISI duration in all three structures. These results show that bursts in spontaneous GPe, STN, and GPi discharge are often preceded or followed by long ISIs, and that burst length, the length of pre- and postburst ISIs, and the length of interburst intervals are related to one another. Complex changes in these interactions may contribute to abnormal information processing in parkinsonism.
机译：已知在帕金森病中基底神经节神经元的爆发放电比正常情况下更常见，但是尚未报道爆发或爆发前后时期的结构变化。在这项研究中，在两个清醒的恒河猴中，在丘脑下核（STN）和内，外苍白节（GPe，GPi）中记录的神经元尖峰序列中检查了爆发的时间结构以及在其之前或之后的神经元放电的时间。通过单侧颈动脉内输注多巴胺能神经毒素1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）使其成为半帕金森病的猴子。通过“惊奇”方法检测到爆裂。在正常状态下，突发之前或之后的尖峰间隔（ISI）通常明显长于平均基线ISI，并且它们的持续时间与突发长度（即尖峰/突发的数量）相关。在所有三种结构中，在突发长度和突发间隔的持续时间之间也发现了显着的相关性。 MPTP处理后，GPe，STN和GPi中爆发放电的发生率和爆发所花费的时间比例增加。 MPTP处理后，STN中爆发长度与爆发前ISI紧密相关，在所有三个结构中，爆发后ISI持续时间都与爆发前ISI紧密相关。这些结果表明，自发GPe，STN和GPi放电中的爆发通常在较长的ISI之前或之后，并且爆发长度，爆发前和爆发后ISI的长度以及爆发间隔的长度彼此相关。这些相互作用的复杂变化可能会导致帕金森氏症的异常信息处理。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号