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首页> 外文期刊>Journal of Neurophysiology >Deep brain stimulation of the substantia nigra pars reticulata improves forelimb akinesia in the hemiparkinsonian rat
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Deep brain stimulation of the substantia nigra pars reticulata improves forelimb akinesia in the hemiparkinsonian rat

机译：大脑深部刺激黑质网状组织可改善半帕金森病大鼠的前肢运动障碍

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Deep brain stimulation (DBS) employing high-frequency stimulation (HFS) is commonly used in the globus pallidus interna (GPi) and the subthalamic nucleus (STN) for treating motor symptoms of patients with Parkinson's disease (PD). Although DBS improves motor function in most PD patients, disease progression and stimulation-induced nonmotor complications limit DBS in these areas. In this study, we assessed whether stimulation of the substantia nigra pars reticulata (SNr) improved motor function. Hemiparkinsonian rats predominantly touched with their unimpaired forepaw >90% of the time in the stepping and limb-use asymmetry tests. After SNr-HFS (150 Hz), rats touched equally with both forepaws, similar to naive and sham-lesioned rats. In vivo, SNr-HFS decreased beta oscillations (12-30 Hz) in the SNr of freely moving hemiparkinsonian rats and decreased SNr neuronal spiking activity from 28 +- 1.9 Hz before stimulation to 0.8 +- 1.9 Hz during DBS in anesthetized animals,also, neuronal spiking activity increased from 7 +- 1.6 to 18 +- 1.6 Hz in the ventromedial portion of the thalamus (VM), the primary SNr efferent. In addition, HFS of the SNr in brain slices from normal and reserpine-treated rat pups resulted in a depolarization block of SNr neuronal activity. We demonstrate improvement of forelimb akinesia with SNr-HFS and suggest that this motor effect may have resulted from the attenuation of SNr neuronal activity, decreased SNr beta oscillations, and increased activity of VM thalamic neurons, suggesting that the SNr may be a plausible DBS target for treating motor symptoms of DBS.
机译：采用高频刺激（HFS）的深部脑刺激（DBS）通常用于苍白球（GPi）和丘脑下核（STN）中，用于治疗帕金森氏病（PD）患者的运动症状。尽管DBS改善了大多数PD患者的运动功能，但疾病进展和刺激引起的非运动并发症限制了这些领域的DBS。在这项研究中，我们评估了刺激黑质网纹（SNr）改善运动功能。在踩踏和肢体使用不对称性测试中，半帕金森氏症大鼠的前肢未受损的比率主要超过90％。在SNr-HFS（150 Hz）之后，大鼠的两只前爪均等地接触，类似于幼稚和假手术的大鼠。在体内，麻醉动物的DBS期间，SNr-HFS将自由运动的半帕金森氏大鼠的SNr的β振荡降低（12-30 Hz），并将SNr神经元的突增活性从刺激前的28 +-1.9 Hz降低至0.8 +-1.9 Hz。 ，在主要SNr发出的丘脑（VM）腹侧部分，神经元突触活动从7 +-1.6 Hz增加到18 +-1.6 Hz。此外，来自正常和利血平治疗的幼犬脑切片中SNr的HFS导致SNr神经元活性的去极化阻滞。我们证明了SNr-HFS可以改善前肢运动障碍，并提示这种运动效应可能是由于SNr神经元活性减弱，SNrβ振荡减少以及VM丘脑神经元活性增加所致，这表明SNr可能是合理的DBS靶点用于治疗DBS的运动症状。

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