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首页> 外文期刊>Journal of Neurophysiology >Interactions between idiothetic cues and external landmarks in the control of place cells and head direction cells.
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Interactions between idiothetic cues and external landmarks in the control of place cells and head direction cells.

机译：在位置单元和头部方向单元的控制中，惯常提示与外部地标之间的相互作用。

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Two types of neurons in the rat brain have been proposed to participate in spatial learning and navigation: place cells, which fire selectively in specific locations of an environment and which may constitute key elements of cognitive maps, and head direction cells, which fire selectively when the rat's head is pointed in a specific direction and which may serve as an internal compass to orient the cognitive map. The spatially and directionally selective properties of these cells arise from a complex interaction between input from external landmarks and from idiothetic cues; however, the exact nature of this interaction is poorly understood. To address this issue, directional information from visual landmarks was placed in direct conflict with directional information from idiothetic cues. When the mismatch between the two sources of information was small (45 degrees), the visual landmarks had robust control over the firing properties of place cells; when the mismatch was larger, however, the firing fields of the place cells were altered radically, and the hippocampus formed a new representation of the environment. Similarly, the visual cues had control over the firing properties of head direction cells when the mismatch was small (45 degrees), but the idiothetic input usually predominated over the visual landmarks when the mismatch was larger. Under some conditions, when the visual landmarks predominated after a large mismatch, there was always a delay before the visual cues exerted their control over head direction cells. These results support recent models proposing that prewired intrinsic connections enable idiothetic cues to serve as the primary drive on place cells and head direction cells, whereas modifiable extrinsic connections mediate a learned, secondary influence of visual landmarks.
机译：已经提出了大鼠大脑中的两种类型的神经元参与空间学习和导航：放置细胞，其在环境的特定位置选择性发射，并且可能构成认知图的关键元素;以及头部方向细胞，其在以下情况下选择性发​​射：大鼠的头部指向特定的方向，并且可以作为内部指南针来定向认知图。这些细胞的空间和方向选择性是源于外部标志和惯用线索的复杂相互作用。但是，这种相互作用的确切性质了解得很少。为了解决此问题，将来自视觉界标的方向信息与来自惯用线索的方向信息直接冲突。当两个信息源之间的不匹配程度较小（45度）时，视觉界标对位置单元的发射特性具有强大的控制;但是，当失配较大时，位置细胞的发射场会发生根本性变化，海马形成了新的环境表征。类似地，当失配较小（45度）时，视觉提示可以控制头部方向单元的发射特性，但是当失配较大时，惯用输入通常优先于视觉界标。在某些情况下，当视觉标志在大的失配之后占主导地位时，在视觉提示对头部方向单元施加控制之前总是会有延迟。这些结果支持了最近的模型，这些模型提出预接线的固有连接使惯用线索能够用作位置单元和头部方向单元的主要驱动力，而可修改的外部连接则介导了视觉界标的学习的，辅助的影响。

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