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首页> 外文期刊>Journal of Neurophysiology >Interdependence of spatial properties and projection patterns of medial vestibulospinal tract neurons in the cat.
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Interdependence of spatial properties and projection patterns of medial vestibulospinal tract neurons in the cat.

机译：猫的前庭内侧脊髓道神经元的空间特性和投射模式的相互依赖性。

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摘要

Activity of vestibular nucleus neurons with axons in the ipsi- or contralateral medial vestibulospinal tract was studied in decerebrate cats during sinusoidal, whole-body rotations in many planes in three-dimensional space. Antidromic activation of axon collaterals distinguished between neurons projecting only to neck segments from those with collaterals to C6 and/or oculomotor nucleus. Secondary neurons were identified by monosynaptic activation after labyrinth stimulation. A three-dimensional maximum activation direction vector (MAD) summarized the spatial properties of 151 of 169 neurons. The majority of secondary neurons (71%) terminated above the C6 segment. Of these, 43% had ascending collaterals to the oculomotor nucleus (VOC neurons), and 57% did not (VC neurons). The majority of VOC and VC neurons projected contralaterally and ipsilaterally, respectively. Most C6-projecting neurons could not be activated from oculomotor nucleus (V-C6 neurons) and projected primarily ipsilaterally. All VO-C6 neurons projected contralaterally. The distributions of MADs for secondary neurons with different projection patterns were different. Most VOC (84%) and contralaterally projecting VC (91%) neurons had MADs close to the activation vector of a semicircular canal pair, compared with 54% of ipsilaterally projecting VC (i-VC) and 39% of V-C6 neurons. Many i-VC (44%) and V-C6 (48%) neurons had responses suggesting convergent input from horizontal and vertical canal pairs. Horizontal and vertical gains were comparable for some, making it difficult to assign a primary canal input. MADs consistent with vertical-vertical canal pair convergence were less common. Type II yaw or type II roll responses were seen for 22% of the i-VC neurons, 68% of the V-C6 neurons, and no VOC cells. VO-C6 neurons had spatial properties between those of VOC and V-C6 neurons. These results suggest that secondary VOC neurons convey semicircular canal pair signals to both ocular and neck motor centers, perhaps linking eye and head movements. Secondary VC and V-C6 neurons carry more processed signals, possibly to drive neck and forelimb reflexes more selectively. Two groups of secondary i-VC neurons exhibited vertical-horizontal canal convergence similar to that present on neck muscles. The vertical-vertical canal convergence present on many neck muscles, however, was not present on medial vestibulospinal neurons. Spatial transformations achieved by the vestibulocollic reflex may occur in part on secondary neurons but further combination of canal signals must take place to generate compensatory muscle activity.
机译：在三维空间中许多平面的正弦，全身旋转过程中，对去大脑的猫研究了同侧或对侧内侧前庭脊髓棘道中前庭核神经元轴突的活动。轴突侧支的抗蠕动激活区别于仅投射到颈段的神经元和那些具有C6和/或动眼神经核的侧支的神经元。通过迷宫刺激后的单突触激活来识别继发神经元。三维最大激活方向矢量（MAD）总结了169个神经元中151个的空间特性。大多数次级神经元（71％）终止于C6段以上。其中，有43％的动眼神经核（VOC神经元）有升侧支，而没有的动眼神经核（VC神经元）有57％。大多数VOC和VC神经元分别在对侧和同侧突出。大多数C6投射神经元无法从动眼神经核（V-C6神经元）激活，而是主要在同侧投射。所有VO-C6神经元都向对侧投射。具有不同投影模式的继发神经元的MAD分布不同。大多数VOC（84％）和对侧突出的VC（91％）神经元的MAD接近半规管对的激活向量，而54％的同侧突出的VC（i-VC）和39％的V-C6神经元。许多i-VC（44％）和V-C6（48％）神经元的反应表明来自水平和垂直管对的会聚输入。在某些情况下，水平和垂直增益是可比的，因此很难分配主要的运河输入。与垂直-垂直管对收敛一致的MAD较少见。在22％的i-VC神经元，68％的V-C6神经元中，没有看到II型偏航或II型侧倾反应，并且没有VOC细胞。 VO-C6神经元的空间特性介于VOC和V-C6神经元之间。这些结果表明，继发性VOC神经元将半圆管对信号传送到眼部和颈部运动中心，这可能与眼睛和头部的运动有关。次级VC和V-C6神经元携带更多经过处理的信号，可能更选择性地驱动颈部和前肢反射。两组继发性i-VC神经元表现出垂直-水平管融合，类似于颈部肌肉上的融合。在许多颈部肌肉中存在垂直-垂直的管汇合，但是在内侧前庭脊髓神经元上不存在。前庭结肠反射所实现的空间转换可能部分发生在继发性神经元上，但是必须发生管信号的进一步组合才能产生代偿性肌肉活动。

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