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首页> 外文期刊>Journal of Neurophysiology >Depression of synaptic efficacy in high- and low-output Drosophila neuromuscular junctions by the molting hormone (20-HE).
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Depression of synaptic efficacy in high- and low-output Drosophila neuromuscular junctions by the molting hormone (20-HE).

机译：蜕皮激素（20-HE）抑制果蝇神经肌肉连接处高输出和低输出的突触功效。

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摘要

The molt-related steroid hormone, 20-hydroxyecdysone (20-HE), was applied to muscles 6 and 7 of third instar larval of Drosophila melanogaster neuromuscular junction preparations to examine if rapid, nongenomic responses could be observed as was shown recently to occur in crustacean neuromuscular junctions. At a dose of 10 microM, the excitatory junction potentials were reduced in amplitude within minutes. To elucidate the site of action of the hormone, focal-macropatch recordings of synaptic currents were obtained over the neuromuscular junctions. The results showed that the high-output (Is) and the low-output (Ib) motor nerve terminals, which innervate muscles 6 and 7, released fewer synaptic vesicles for each stimulation while exposed to 20-HE. Because the size and shape of synaptic currents from spontaneous releases did not change, the effects of the 20-HE are presynaptic. The rapid effects of this hormone may account in part for the quiescent behavior associated with molts among insects and crustaceans.
机译：将与蜕皮有关的类固醇激素20-羟基蜕皮激素（20-HE）应用于果蝇神经肌肉接头制剂三龄幼虫的肌肉6和7，以检查是否可以观察到快速的非基因组反应，如最近在甲壳类神经肌肉接头。在10 microM的剂量下，兴奋性连接电位在数分钟内幅度减小。为了阐明该激素的作用部位，在神经肌肉接头上获得了突触电流的局部宏记录。结果表明，高输出（Is）和低输出（Ib）支配肌肉6和7的运动神经末梢，每次暴露于20-HE时，每次刺激释放的突触囊泡较少。由于自发释放的突触电流的大小和形状没有改变，因此20-HE的作用是突触前的。这种激素的快速作用可能部分解释了与昆虫和甲壳类动物蜕皮有关的静态行为。

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