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首页> 外文期刊>Journal of Neurophysiology >C-fiber depletion alters response properties of neurons in trigeminal nucleus principalis.
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C-fiber depletion alters response properties of neurons in trigeminal nucleus principalis.

机译：C纤维耗竭会改变三叉神经原核中神经元的反应特性。

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摘要

The effects of C-fiber depletion induced by neonatal capsaicin treatment on the functional properties of vibrissa-sensitive low-threshold mechanoreceptive (LTM) neurons in the rat trigeminal nucleus principalis were examined in adult rats. Neonatal rats were injected either with capsaicin or its vehicle within 48 h of birth. The depletion of unmyelinated afferents was confirmed by the significant decrease in plasma extravasation of Evan's blue dye induced in the hindlimb skin of capsaicin-treated rats by cutaneous application of mustard oil and by the significant decrease of unmyelinated fibers in both the sciatic and infraorbital nerves. The mechanoreceptive field (RF) and response properties of 31 vibrissa-sensitive neurons in capsaicin-treated rats were compared with those of 32 vibrissa-sensitive neurons in control (untreated or vehicle-treated) rats. The use of electronically controlled mechanical stimuli allowed quantitative analysis of response properties of vibrissa-sensitive neurons; these included the number of center- and surround-RF vibrissae within the RF (i.e., those vibrissae which when stimulated elicited >/=1 and <1 action potential per stimulus, respectively), the response magnitude and latency, and the selectivity of responses to stimulation of vibrissae in different directions with emphasis on combining both the response magnitude and direction of vibrissal deflection in a vector analysis. Neonatal capsaicin treatment was associated with significant increases in the total number of vibrissae, in the number of center-RF vibrissae per neuronal RF, and in the percentage of vibrissa-sensitive neurons that also responded to stimulation of other types of orofacial tissues. Compared with control rats, capsaicin-treated rats showed significant increases in the response magnitude to stimulation of surround-RF vibrissae as well as in response latency variability to stimulation of both center- and surround-RF vibrissae. C-fiber depletion also significantly altered the directional selectivity of responses to stimulation of vibrissae. For neurons with multiple center-RF vibrissae, the proportion of center-RF vibrissae with net vector responses oriented toward the same quadrant was significantly less in capsaicin-treated compared with control rats. These changes in the functional properties of principalis vibrissa-sensitive neurons associated with marked depletion of C-fiber afferents are consistent with similarly induced alterations in LTM neurons studied at other levels of the rodent somatosensory system, and indeed may contribute to alterations previously described in the somatosensory cortex of adult rodents. Furthermore, these results provide additional support to the view that C fibers may have an important role in shaping the functional properties of LTM neurons in central somatosensory pathways.
机译：在成年大鼠中检查了新生辣椒素治疗引起的C纤维耗竭对大鼠三叉神经核中触须敏感的低阈值机械感受性（LTM）神经元功能特性的影响。新生大鼠在出生后48小时内注射辣椒素或其载体。通过皮肤施用芥子油，在辣椒素处理的大鼠后肢皮肤中诱导的伊文思蓝染料的血浆外渗显着减少，以及坐骨神经和眶下神经中无髓鞘纤维的显着减少，证实了无髓鞘传入神经的减少。比较了在辣椒素处理的大鼠中的31个触须敏感神经元的机械感受野（RF）和响应特性与在对照（未经处理或媒介物处理的）大鼠中的32个触须敏感神经元的力学感受性场和响应特性。电控机械刺激的使用允许对触须敏感神经元的响应特性进行定量分析。这些包括RF内中心RF和环绕RF触须的数量（即，当被刺激时，每个刺激分别引起> / = 1和<1动作电位的触须），响应幅度和潜伏期以及响应的选择性在不同方向上刺激触须，重点是在矢量分析中结合响应幅度和触角偏转方向。新生儿辣椒素治疗与触毛总数，每个神经元RF的中心RF触毛数量以及对其他类型的口面组织刺激也有响应的触敏神经元的百分比显着增加有关。与对照组大鼠相比，用辣椒素处理的大鼠对周围RF弧线刺激的响应幅度和对中心RF和周围RF弧线刺激的响应潜伏期变异性均显着增加。 C纤维的消耗还显着改变了对触须刺激的响应的方向选择性。对于具有多个中心RF触须的神经元，与对照组相比，在辣椒素处理中，具有朝向相同象限的净矢量响应的中心RF触须的比例明显更少。与C纤维传入纤维明显耗竭相关的原理的触须触须敏感神经元的这些变化与在啮齿动物体感系统其他水平上研究的LTM神经元的类似诱导变化一致，并且确实可能​​导致了先前描述的变化。成年啮齿动物的体感皮层。此外，这些结果为以下观点提供了额外的支持：C纤维在塑造LTM神经元在中央体感通路中的功能特性方面可能起重要作用。

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