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首页> 外文期刊>Journal of Neurophysiology >Ongoing and stimulus-evoked activity of sympathetically correlated neurons in the intermediate zone and dorsal horn of acutely spinalized rats.
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Ongoing and stimulus-evoked activity of sympathetically correlated neurons in the intermediate zone and dorsal horn of acutely spinalized rats.

机译：急性脊髓大鼠中间区和背角中交感相关神经元的持续活动和刺激诱发的活动。

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We have shown previously that in the acutely spinalized anesthetized rat the activities of many dorsal horn interneurons (DHN) at the T(10) level are correlated positively with both ongoing and stimulus-evoked renal sympathetic nerve activity (RSNA) and therefore may belong to networks generating RSNA after acute, cervical, spinal transection. In the present study, we recorded from both DHN and interneurons in the intermediate zone (IZN) of the T(10) spinal segment in acutely C(1)-transected, chloralose-anesthetized, artificially respired rats. The activities of a similar percentage of IZN and DHN were correlated positively with ongoing RSNA, but the peaks of spike-triggered averages of RSNA based on the activity of IZN were larger, relative to dummy averages, than spike-triggered averages of RSNA based on the activity of DHN. Sympathetically correlated DHN and IZN differed in their responses to noxious somatic stimuli. Most correlated DHN had relatively simple somatic fields; they were excited by noxious stimulation of the T(10) and nearby dermatomes and inhibited by stimulation of more distal dermatomes. As we have shown previously, the excitatory and inhibitory fields of these neurons were very similar to fields that, respectively, excited and inhibited RSNA. On the other hand, the somatic fields of 50% of sympathetically correlated IZN were significantly more complex, indicating a difference between either the inputs or the processing properties of IZN and DHN. Sympathetically correlated IZN and DHN also differed in their responses to colorectal distension (CRD), a noxious visceral stimulus. CRD increased RSNA in 11/15 rats and increased the activity of most sympathetically correlated T(10) IZN. On the other hand, CRD decreased the activity of a majority of sympathetically correlated T(10) DHN. These observations suggest that the same stimulus may differentially affect separate, putative, sympathoexcitatory pathways, exciting one and inhibiting the other. Thus the magnitude and even the polarity of responses to a given stimulus may be determined by the modality and location of the stimulus, the degree to which multiple pathways are affected by the stimulus, and the ongoing activity of presympathetic neurons, at multiple rostrocaudal levels, before stimulation. A multipathway system may explain the variability in autonomic responses to visceral and somatic stimuli exhibited in spinally injured patients.
机译：先前我们已经证明，在急性脊髓麻醉的大鼠中，许多背角中间神经元（DHN）在T（10）水平的活动与正在进行的和刺激诱发的肾交感神经活动（RSNA）均呈正相关，因此可能属于网络在急性，颈椎，脊柱横断后产生RSNA。在本研究中，我们记录了从DHN和中间神经元在急性C（1）横切，氯醛糖麻醉的人工呼吸大鼠的T（10）脊柱节段的中间区（IZN）中的情况。相似百分比的IZN和DHN的活性与进行中的RSNA呈正相关，但相对于虚拟平均值，基于IZN活性的RSNA峰值触发平均值的峰值要大于基于RSN的RSNA峰值触发平均值。 DHN的活性。交感神经相关的DHN和IZN对有害的躯体刺激的反应不同。最相关的DHN具有相对简单的体细胞场。他们对T（10）和附近的皮具的有害刺激而兴奋，而对更多远端皮具的刺激则抑制了它们。正如我们之前所显示的，这些神经元的兴奋性和抑制性场分别类似于激发和抑制RSNA的场。另一方面，与交感相关的IZN的50％的体场显着更复杂，表明IZN和DHN的输入或处理特性之间存在差异。交感神经相关的IZN和DHN对大肠扩张（CRD）（一种有害的内脏刺激）的反应也有所不同。 CRD增加了11/15大鼠的RSNA，并增加了大多数与交感神经相关的T（10）IZN的活性。另一方面，CRD降低了大多数交感神经相关的T（10）DHN的活性。这些观察结果表明，相同的刺激可能会不同地影响单独的，假定的，交感兴奋性途径，从而激发一个而抑制另一个。因此，对给定刺激的反应的大小甚至极性可以由刺激的方式和位置，刺激对多种途径的影响程度以及交感神经元在多个额尾脑水平上正在进行的活动来确定，刺激之前。多通路系统可以解释对脊髓损伤患者表现出的对内脏和躯体刺激的自主反应的变异性。

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