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首页> 外文期刊>Journal of Neurophysiology >Presynaptic and interactive peptidergic modulation of reticulospinal synaptic inputs in the lamprey.
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Presynaptic and interactive peptidergic modulation of reticulospinal synaptic inputs in the lamprey.

机译：七lamp鳗中网状脊髓突触输入的突触前和相互作用的肽能调节。

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The modulatory effects of neuropeptides on descending inputs to the spinal cord have been examined by making paired recordings from reticulospinal axons and spinal neurons in the lamprey. Four peptides were examined; peptide YY (PYY) and cholecystokinin (CCK), which are contained in brain stem reticulospinal neurons, and calcitonin-gene-related peptide (CGRP) and neuropeptide Y (NPY), which are contained in primary afferents and sensory interneurons, respectively. Each of the peptides reduced the amplitude of monosynaptic reticulospinal-evoked excitatory postsynaptic potentials (EPSPs). The modulation appeared to be presynaptic, because postsynaptic input resistance and membrane potential, the amplitude of the electrical component of the EPSP, postsynaptic responses to glutamate, and spontaneous miniature EPSP amplitudes were unaffected. In addition, none of the peptides affected the pattern of N-methyl-D-aspartate (NMDA)-evoked locomotor activity in the isolated spinal cord. Potential interactions between the peptides were also examined. The "brain stem peptides" CCK and PYY had additive inhibitory effects on reticulospinal inputs, as did the "sensory peptides" CGRP and NPY. Brain stem peptides also had additive inhibitory effects when applied with sensory peptides. However, sensory peptides increased or failed to affect the amplitude of reticulospinal inputs in the presence of the brain stem peptides. These interactive effects also appear to be mediated presynaptically. The functional consequence of the peptidergic modulation was investigated by examining spinal ventral root responses elicited by brain stem stimulation. CCK and CGRP both reduced ventral root responses, although in interaction both increased the response. These results thus suggest that neuropeptides presynaptically influence the descending activation of spinal locomotor networks, and that they can have additive or novel interactive effects depending on the peptides examined and the order of their application.
机译：通过从七the鳗的网状脊髓轴突和脊髓神经元进行配对记录，已经检查了神经肽对脊髓降序输入的调节作用。检查了四种肽;脑干网状棘突神经元中包含的YY肽（PYY）和胆囊收缩素（CCK），初级传入和感觉神经元中分别包含降钙素基因相关肽（CGRP）和神经肽Y（NPY）。每种肽都降低了单突触网状脊髓诱发的兴奋性突触后电位（EPSPs）的幅度。调节似乎是突触前的，因为突触后的输入电阻和膜电位，EPSP的电子成分的振幅，对谷氨酸的突触后的反应以及自发的微型EPSP振幅均不受影响。另外，在分离的脊髓中，没有一种肽影响N-甲基-D-天冬氨酸（NMDA）引起的运动功能的模式。还检查了肽之间的潜在相互作用。 “脑干肽” CCK和PYY对网状脊椎输入具有累加抑制作用，“感觉肽” CGRP和NPY也具有抑制作用。当与感觉肽一起使用时，脑干肽也具有附加的抑制作用。然而，在存在脑干肽的情况下，感觉肽增加或不能影响网状脊髓输入的幅度。这些交互作用似乎也是先突触地介导的。通过检查脑干刺激引起的脊髓腹侧根反应来研究肽能调节的功能后果。 CCK和CGRP均降低了腹根反应，尽管在相互作用中均增加了反应。因此，这些结果表明，神经肽预突触地影响脊髓运动网络的下降激活，并且根据所检查的肽及其应用顺序，它们可能具有累加或新颖的相互作用。

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