...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neurophysiology >Long-term potentiation in an isolated peripheral nerve-spinal cord preparation.
【24h】

Long-term potentiation in an isolated peripheral nerve-spinal cord preparation.

机译：在隔离的周围神经脊髓脊髓制剂中的长期增强作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

1. Long-lasting increases in synaptic efficacy following repetitive stimulation have been demonstrated at several sites in the CNS, where they are collectively termed long-term potentiation (LTP). LTP is of interest with respect to its presumptive relationship to learning and memory in hippocampus. In the spinal cord in vivo, an LTP-like phenomenon is thought to underlie the allodynia and hyperalgesia that follows some peripheral injuries. 2. We investigated the capacity of the isolated neonatal rat spinal cord to sustain a long-lasting increase in a nociceptive-related slow ventral root potential (sVRP) recorded from a lumbar root after a tetanic train of stimuli to the peripheral cutaneous saphenous nerve. Stimuli were delivered at a low constant (0.02 s-1) frequency during a 30-min control period. A tetanic stimulus train (10 s-1 for 60 s) was then given followed by a resumption of low (0.02 s-1) frequency stimulation. Potentiation was defined as an increase in sVRP area > 2 SD above control mean. 3. Twenty of 20 preparations showed immediate posttetanic potentiation. In 13 of the 20, potentiation was maintained for > or = 1 h after the tetanic stimulus train. 4. Potentiation was dependent on activation of C fibers during the inducing train; stimuli below C-fiber threshold, activating only A fibers, were ineffective. Potentiation was selectively expressed by a long-latency component of the sVRP elicited by stimuli at a strength that evoked both A- and C-fiber responses in the nerve.(ABSTRACT TRUNCATED AT 250 WORDS)
机译：1.在中枢神经系统的几个部位已经证实了重复刺激后突触功效的持久增加，这些部位统称为长期增强（LTP）。 LTP与海马的学习和记忆的推测关系令人感兴趣。在体内脊髓中，LTP样现象被认为是某些周围损伤后的异常性疼痛和痛觉过敏的基础。 2.我们研究了分离的新生大鼠脊髓在腰部根系的强直​​性刺激后从腰根记录的伤害相关慢腹侧根电位（sVRP）持续长期增加的能力。在30分钟的控制期内，刺激以较低的恒定（0.02 s-1）频率传递。然后给予强直性刺激训练（10 s-1，持续60 s），然后恢复低频（0.02 s-1）刺激。增强作用定义为sVRP面积比对照平均值增加2 SD。 3. 20种制剂中有20种显示出立即的强直性增强作用。在20个刺激中，有13个在强直性刺激训练后维持增强作用>或= 1小时。 4.增强取决于诱导过程中碳纤维的活化;低于C纤维阈值的刺激（仅激活A纤维）无效。增强作用是由刺激引起的sVRP的长时延成分选择性表达的，其强度引起神经中的A纤维和C纤维反应（摘要截断为250字）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号