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首页> 外文期刊>Journal of Neurophysiology >Effects of local inactivation of monkey medial frontal cortex in learning of sequential procedures.
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Effects of local inactivation of monkey medial frontal cortex in learning of sequential procedures.

机译：猴子内侧额叶皮层局部失活在顺序程序学习中的作用。

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摘要

To examine the role of the medial frontal cortex, supplementary motor area (SMA), and pre-SMA in the acquisition and control of sequential movements, we locally injected muscimol into 43 sites in the medial frontal cortex while monkeys (n = 2) performed a sequential button-press task. In this task, the monkey had to press two of 16 (4 x 4 matrix) buttons illuminated simultaneously in a predetermined order. A total of five pairs were presented in a fixed order for completion of a trial. To clarify the differential contribution of the medial frontal cortex for new acquisition and control of sequential movements, we used novel and learned sequences (that had been learned after extensive practice). We found that the number of errors increased for novel sequences, but not for learned sequences, after pre-SMA inactivations. A similar, but insignificant, trend was observed after SMA injections. The reaction time of button presses for both novel and learned sequences was prolonged by inactivations of both SMA and pre-SMA, with a trend for the effect to be larger for SMA inactivations. These findings suggest that the medial frontal cortex, especially pre-SMA, is related to the acquisition, rather than the storage or execution, of the correct order of button presses.
机译：为了检查内侧额叶皮质，辅助运动区（SMA）和SMA前体在连续运动的获取和控制中的作用，我们在猴子（n = 2）进行局部注射麝香酚到内侧额叶皮质的43个部位顺序的按键任务。在此任务中，猴子必须按预定顺序同时按下16个（4 x 4矩阵）照明按钮中的两个。总共以固定顺序提供了五对，以完成试验。为了阐明内侧额叶皮层对于新的获取和控制顺序运动的不同作用，我们使用了新颖的和学到的序列（经过广泛实践后才了解到）。我们发现，SMA前失活后，新序列的错误数量增加，但学习序列的错误数量却没有增加。 SMA注射后观察到类似但微不足道的趋势。 SMA和pre-SMA均被灭活，从而使新颖和学习序列的按钮按下反应时间延长，SMA灭活的效果趋于更大。这些发现表明，内侧额叶皮层，特别是SMA前，与正确按下按钮的顺序有关，而不是与存储或执行有关。

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