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首页> 外文期刊>Journal of Neurophysiology >Correlation between the activity of single auditory cortical neurons and sound-localization behavior in the macaque monkey.
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Correlation between the activity of single auditory cortical neurons and sound-localization behavior in the macaque monkey.

机译：猕猴中单个听觉皮层神经元的活动与声音定位行为之间的相关性。

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Lesion studies have indicated that the auditory cortex is crucial for the perception of acoustic space, yet it remains unclear how these neurons participate in this perception. To investigate this, we studied the responses of single neurons in the primary auditory cortex (AI) and the caudomedial field (CM) of two monkeys while they performed a sound-localization task. Regression analysis indicated that the responses of approximately 80% of neurons in both cortical areas were significantly correlated with the azimuth or elevation of the stimulus, or both, which we term "spatially sensitive." The proportion of spatially sensitive neurons was greater for stimulus azimuth compared with stimulus elevation, and elevation sensitivity was primarily restricted to neurons that were tested using stimuli that the monkeys also could localize in elevation. Most neurons responded best to contralateral speaker locations, but we also encountered neurons that responded best to ipsilateral locations and neurons that had their greatest responses restricted to a circumscribed region within the central 60 degrees of frontal space. Comparing the spatially sensitive neurons with those that were not spatially sensitive indicated that these two populations could not be distinguished based on either the firing rate, the rate/level functions, or on their topographic location within AI. Direct comparisons between the responses of individual neurons and the behaviorally measured sound-localization ability indicated that proportionally more neurons in CM had spatial sensitivity that was consistent with the behavioral performance compared with AI neurons. Pooling the responses across neurons strengthened the relationship between the neuronal and psychophysical data and indicated that the responses pooled across relatively few CM neurons contain enough information to account for sound-localization ability. These data support the hypothesis that auditory space is processed in a serial manner from AI to CM in the primate cerebral cortex.
机译：病变研究表明，听觉皮层对于听觉空间的感知至关重要，但目前尚不清楚这些神经元如何参与这种感知。为了对此进行研究，我们研究了两只猴子在执行声音定位任务时在主要听觉皮层（AI）和伪内侧场（CM）中的单个神经元的响应。回归分析表明，两个皮层区域中大约80％的神经元的反应与刺激的方位角或高度或两者均显着相关，我们称之为“空间敏感”。与刺激升高相比，刺激方位角对空间敏感神经元的比例更大，并且升高敏感性主要限于使用猴子也可以定位在海拔高度的刺激进行测试的神经元。大多数神经元对对侧说话者位置的反应最佳，但我们也遇到对同侧位置反应最佳的神经元，其最大反应仅限于额叶中央60度以内的外接区域的神经元。将空间敏感的神经元与非空间敏感的神经元进行比较表明，无法基于放电速率，速率/水平功能或它们在AI中的地形位置来区分这两个种群。单个神经元的响应与行为测得的声音定位能力之间的直接比较表明，与AI神经元相比，CM中成比例地更多的神经元具有与行为表现一致的空间敏感性。汇集跨神经元的反应加强了神经元和心理物理数据之间的关系，并表明汇集于相对较少的CM神经元的反应包含足够的信息以说明声音定位能力。这些数据支持以下假设：在灵长类大脑皮层中，从AI到CM以连续的方式处理听觉空间。

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