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首页> 外文期刊>Journal of Neurophysiology >Spinal allografts of adrenal medulla block nociceptive facilitation in the dorsal horn.
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Spinal allografts of adrenal medulla block nociceptive facilitation in the dorsal horn.

机译：肾上腺髓质的脊髓同种异体移植物阻碍了背角的伤害感受性促进。

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Transplantation of chromaffin cells into the lumbar subarachnoid space has been found to produce analgesia, most conspicuously against chronic neuropathic pain. To ascertain the neurophysiological mechanism, we recorded electrical activity from wide-dynamic-range dorsal horn neurons in vivo, measuring the short-lasting homosynaptic facilitatory effect known as windup, which is induced by repetitive C-fiber input. Rats were given adrenal medulla allografts, or, as controls, striated-muscle allografts. The adrenal-transplanted rats showed analgesia 3--4 wk after transplantation, measured as a reduction in flinching reflexes 30--55 min after subcutaneous formalin injection. Recordings were made under halothane anesthesia, 3--7 days following the behavioral testing. The average C-fiber response and subsequent afterdischarge were facilitated severalfold in control rats by 1-Hz cutaneous electrical stimulation. Such facilitation was essentially absent in adrenal-transplanted animals and also in the A-fiber response of both preparations. Extirpation of transplanted tissue several hours prior to recording did not significantly affect this difference. In conclusion, the adrenal transplants block short-term spinal nociceptive facilitation, probably by stimulating some persistent cellular process that may be an important determinant, but not the only one, of their analgesic effect.
机译：已经发现嗜铬细胞移植到腰蛛网膜下腔会产生镇痛作用，最明显的是对慢性神经性疼痛的镇痛作用。为了确定神经生理机制，我们记录了体内广泛动态范围的背角神经元的电活动，测量了由重复C纤维输入引起的短时同质突触促进作用，称为缠绕。给大鼠肾上腺髓质同种异体移植物，或作为横纹肌同种异体移植物作为对照。肾上腺移植的大鼠在移植后3-3-4 wk表现出镇痛作用，测量方法是皮下注射福尔马林30--55分钟后缩颈反射减少。行为测试后3--7天，在氟烷麻醉下进行记录。通过1 Hz皮肤电刺激，对照组大鼠的平均C纤维反应和随后的放电后均得到了几倍的促进。肾上腺移植的动物以及两种制剂的A纤维反应都基本上没有这种促进作用。记录前数小时，移植组织的灭绝并没有显着影响这种差异。总之，肾上腺移植可能通过刺激一些持续的细胞过程来阻断短期的脊髓伤害性促进作用，这可能是其止痛作用的重要决定因素，但不是唯一因素。

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