...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neurophysiology >Selective stimulation of cat sciatic nerve using an array of varying-length microelectrodes.
【24h】

Selective stimulation of cat sciatic nerve using an array of varying-length microelectrodes.

机译：使用一系列不同长度的微电极选择性刺激猫坐骨神经。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Restoration of motor function to individuals who have had spinal cord injuries or stroke has been hampered by the lack of an interface to the peripheral nervous system. A suitable interface should provide selective stimulation of a large number of individual muscle groups with graded recruitment of force. We have developed a new neural interface, the Utah Slanted Electrode Array (USEA), that was designed to be implanted into peripheral nerves. Its goal is to provide such an interface that could be useful in rehabilitation as well as neuroscience applications. In this study, the stimulation capabilities of the USEA were evaluated in acute experiments in cat sciatic nerve. The recruitment properties and the selectivity of stimulation were examined by determining the target muscles excited by stimulation via each of the 100 electrodes in the array and using force transducers to record the force produced in these muscles. It is shown in the results that groups of up to 15 electrodes were inserted into individual fascicles. Stimulation slightly above threshold was selective to one muscle group for most individual electrodes. At higher currents, co-activation of agonist but not antagonist muscles was observed in some instances. Recruitment curves for the electrode array were broader with twitch thresholds starting at much lower currents than for cuff electrodes. In these experiments, it is also shown that certain combinations of electrode pairs, inserted into an individual fascicle, excite fiber populations with substantial overlap, whereas other pairs appear to address independent populations. We conclude that the USEA permits more selective stimulation at much lower current intensities with more graded recruitment of individual muscles than is achieved by conventional cuff electrodes.
机译：由于缺乏与周围神经系统的接口，阻碍了脊髓损伤或中风患者的运动功能恢复。合适的界面应能选择性地刺激大量的个体肌肉群，并逐步吸收力量。我们已经开发了一种新的神经接口，犹他州倾斜电极阵列（USEA），该接口旨在植入周围神经中。其目标是提供一种在康复以及神经科学应用中可能有用的接口。在这项研究中，在猫坐骨神经的急性实验中评估了USEA的刺激能力。通过确定通过阵列中的100个电极中的每一个电极的刺激而激发的目标肌肉，并使用力传感器记录这些肌肉中产生的力，来检查募集特性和刺激的选择性。结果表明，将多达15个电极的组插入到各个分册中。对于大多数单个电极，略高于阈值的刺激对一个肌肉群具有选择性。在更高的电流下，在某些情况下观察到激动剂而不是拮抗肌的共激活。与袖带电极相比，电极阵列的招募曲线更宽，抽搐阈值的电流要低得多。在这些实验中，还显示出插入一对单独的束中的电极对的某些组合会激发具有大量重叠的纤维群，而其他电极对则似乎是针对独立的群。我们得出的结论是，与传统的袖带电极相比，USEA可以在更低的电流强度下进行更多选择性刺激，并且可以更均匀地吸收单个肌肉。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号