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首页> 外文期刊>Journal of Neurophysiology >Hippocampal synaptic transmission and plasticity are preserved in myosin Va mutant mice.
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Hippocampal synaptic transmission and plasticity are preserved in myosin Va mutant mice.

机译：海马突触传递和可塑性保留在肌球蛋白Va突变小鼠中。

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Recent studies have identified myosin Va as an organelle motor that may have important functions in neurons. Abundantly expressed at the hippocampal postsynaptic density, it interacts with protein complexes involved in synaptic plasticity. It is also located in presynaptic terminals and may function to recruit vesicles in the reserve pool to the active zone. Dilute-lethal mice are spontaneous myosin Va mutants and have severe neurological symptoms. We studied hippocampal physiology at CA3-CA1 excitatory synapses in dilute-lethal mutant mice to test the hypothesis that myosin Va plays a role in pre- or postsynaptic elements of synaptic transmission. In all assays performed, the mutant synapses appeared to be functioning normally, both pre- and postsynaptically. These data suggest that myosin Va is not essential for the synaptic release machinery, postsynaptic receptor composition, or plasticity at this synapse, but does not exclude significant roles for myosin Va in other cell types nor potential compensation by other myosin V isoforms.
机译：最近的研究已将肌球蛋白Va鉴定为可能在神经元中具有重要功能的细胞器运动。在海马突触后密度大量表达，它与参与突触可塑性的蛋白质复合物相互作用。它也位于突触前末端，可能起着将储备池中的小泡募集到活动区的作用。稀致死小鼠是自发性肌球蛋白Va突变体，具有严重的神经系统症状。我们研究了稀释致死突变小鼠中CA3-CA1兴奋性突触的海马生理，以检验肌球蛋白Va在突触传递之前或之后的突触元件中起作用的假设。在进行的所有测定中，突变突触似乎在突触前和突触后均正常起作用。这些数据表明，肌球蛋白Va对于突触释放机制，突触后受体组成或在该突触处的可塑性不是必需的，但不排除肌球蛋白Va在其他细胞类型中的重要作用，也不排除其他肌球蛋白V同工型的潜在补偿。

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