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首页> 外文期刊>Journal of Neuroscience Methods >Neurological sequelae and long-term behavioural assessment of rats with transient middle cerebral artery occlusion.
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Neurological sequelae and long-term behavioural assessment of rats with transient middle cerebral artery occlusion.

机译：大鼠短暂性中脑动脉阻塞的神经后遗症和长期行为评估。

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摘要

Animal models of stroke, notably transient middle cerebral artery occlusion (MCAo), are used to assess the efficacy of pharmacological and transplant treatments. Long-term studies (>1 month) of the functional effects of treatments in animal models are required to predict treatments likely to improve dysfunctions associated with stroke damage. These pre-clinical studies require (1) optimum post-operative care to ensure long-term survival, (2) methods for assignment of rats to groups with equivalent impairments to reduce variability and enhance detection of treatment effects, and (3) behavioural tests that detect long-term stable deficits. For long-term functional assessment, a battery of behavioural tests sensitive to a range of deficits observed after MCAo was developed. The bilateral asymmetry test evaluated the time course of sensory neglect. Deficits of motor integration were examined in the footfault test, and motor bias was assessed by pharmacological stimulation of rotation. The water maze was used to detect long-term deficits in spatial information processing. Long-term differences between control and MCAo animals in this battery of tests indicate that the protocol provides an efficient assessment suitable for evaluating treatment outcomes in pre-clinical studies of stroke, and that the post-operative care procedure and method of assignment to groups were effective.
机译：中风的动物模型，尤其是短暂性脑中动脉闭塞（MCAo），用于评估药理和移植治疗的功效。需要对动物模型中的治疗功能进行长期研究（> 1个月），以预测可能改善与中风损害相关的功能障碍的治疗。这些临床前研究需要（1）最佳的术后护理以确保长期存活，（2）将大鼠分配到具有同等损伤的组以减少变异性并增强对治疗效果的检测的方法，以及（3）行为测试检测长期稳定的赤字。对于长期功能评估，开发了一系列对MCAo之后观察到的缺陷敏感的行为测试。双边不对称测试评估了感觉疏忽的时间过程。在脚踩踏板测试中检查了运动整合的不足，并通过药理学上的旋转刺激来评估运动偏倚。水迷宫用于检测空间信息处理中的长期缺陷。在这一系列测试中，对照动物和MCAo动物之间的长期差异表明，该协议提供了适合评估中风临床前研究中治疗效果的有效评估，并且术后护理程序和分组方法为有效。

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