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首页> 外文期刊>Journal of Neuroscience Methods >Concurrent evaluation of locomotor response to novelty and propensity toward cocaine conditioned place preference in mice.
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Concurrent evaluation of locomotor response to novelty and propensity toward cocaine conditioned place preference in mice.

机译：同时评估运动对新颖性和对可卡因条件的偏好的位置反应。

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摘要

Neural and physiological factors underlying individual differences in the vulnerability to drug abuse are the major questions remained to be determined. The present study described new methods that concurrently assess the relationship between locomotor response to novelty and conditioned place preference (CPP) for cocaine in mice using a novel activity monitor, SCANET. The activity monitor simultaneously measured the distance traveled and the amount of time spent in each side of a two-compartment CPP chamber, and the latency to the first entry into the other side of the CPP chamber. Mice were divided into two groups according to their locomotor response to the first exposure to the CPP chamber during a preconditioning session; high-responder (HR) and low-responder (LR) mice. Following conditioning sessions, the CPP score was shown to be higher in LR mice than in HR mice, especially at low doses of cocaine. In a separate experiment with SCANET, we measured the latency to the first entry into the white-floored compartment from the black-floored compartment of the CPP chamber as an index of anxiety-like behavior. The latency was significantly prolonged in the LR group as compared with the HR group. Thus, the new methods described here are considered to be useful for examining animal models of drug addiction with respect to anxiety-like behavior.
机译：吸毒脆弱性个体差异背后的神经和生理因素是尚待确定的主要问题。本研究描述了新方法，该方法同时使用新型活动监测器SCANET评估小鼠对新奇的运动反应与可卡因的条件性位置偏爱（CPP）之间的关系。活动监控器同时测量了两室CPP腔室每一侧的行进距离和所花费的时间，以及首次进入CPP腔室另一侧的等待时间。根据小鼠在预处理阶段对首次暴露于CPP腔室的运动反应，将其分为两组。高响应者（HR）和低响应者（LR）小鼠。经过调理后，LR小鼠的CPP评分高于HR小鼠，尤其是低剂量可卡因时。在使用SCANET进行的另一项实验中，我们测量了CPP室黑底隔室首次进入白底隔室的等待时间，以此作为类似焦虑行为的指标。与HR组相比，LR组的潜伏期显着延长。因此，这里描述的新方法被认为对于检查类似焦虑行为的药物成瘾的动物模型很有用。

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