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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Locomotor response to novelty does not predict cocaine place preference conditioning in rats.
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Locomotor response to novelty does not predict cocaine place preference conditioning in rats.

机译：运动对新奇的反应不能预测可卡因在大鼠中的位置偏爱条件。

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Previous studies have demonstrated that rats showing a strong locomotor response to a novel environment have a greater locomotor response to psycho-stimulant drugs and more rapidly acquire intravenous self-administration of amphetamine. In this report, we examined whether these high-responder (HR) rats would develop place-preference conditioning with cocaine more readily than low-responder (LR) rats. Neither group of rats developed conditioned place preference for cocaine, 2.5 mg/kg, intraperitoneally (IP). Both groups of rats developed conditioned place preference for cocaine, 5.0 and 15 mg/kg, IP. However, we could not find any evidence of enhanced conditioning in the HR rats. HR rats did show a greater locomotor response to cocaine, 15 mg/kg, IP, and the locomotor response of HR and LR rats to cocaine correlated with their response to a novel environment. We conclude that using the place-preference procedure, HR and LR rats do not differ in the rewarding effect of cocaine.
机译：先前的研究表明，对新环境表现出强烈运动反应的大鼠对心理刺激药物的运动反应更大，并且可以更快地获得苯丙胺的静脉内自我给药。在本报告中，我们检查了这些高反应性（HR）大鼠是否比低反应性（LR）大鼠更容易用可卡因开发位置偏好条件。两组大鼠均未出现腹膜内（IP）可卡因2.5 mg / kg的条件位置偏爱。两组大鼠均对IP可卡因，5.0和15 mg / kg的条件适应性偏爱。但是，我们找不到在HR大鼠中增强条件的任何证据。 HR大鼠确实表现出对可卡因的更大的运动反应（15 mg / kg，IP），而HR和LR大鼠对可卡因的运动反应与它们对新环境的反应相关。我们得出结论，使用位置偏好程序，HR和LR大鼠在可卡因的奖励作用方面没有差异。

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