...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neuroscience Methods >Subcutaneous administration of nimodipine improves bioavailability in rabbits.
【24h】

Subcutaneous administration of nimodipine improves bioavailability in rabbits.

机译：尼莫地平的皮下给药改善了兔子的生物利用度。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We compared subcutaneous and oral methods of nimodipine administration to determine a method of nimodipine administration that maintained serum levels at or above the optimal therapeutic concentration (7ng/ml). Plasma concentrations of nimodipine were measured in New Zealand White rabbits (2.6-3.9kg). First, peak plasma concentration (C(max)), time to reach peak plasma concentration (T(max)), and area under the curve (AUC) parameters were calculated and compared between animals receiving oral or subcutaneous nimodipine (5-15mg/kg). Next, plasma concentrations were measured 24h after subcutaneous administration of 2.5mg/kg of nimodipine in healthy animals and animals with experimentally induced SAH. C(max), T(max) and AUC parameters were significantly greater for subcutaneous compared to oral nimodipine administration, irrespective of dose. Mean nimodipine concentrations at 24h were >7ng/ml in both healthy animals (12.9 +/- 10.0ng/ml) and in animals with SAH (11.8 +/- 4.6ng/ml) that received 2.5mg/kg ofsubcutaneous nimodipine. In this model, the subcutaneous method of nimodipine administration consistently maintains plasma levels at or above the optimal therapeutic concentration, whereas oral administration fails to do so.
机译：我们比较了尼莫地平的皮下和口服给药方法，以确定将血清水平维持在或高于最佳治疗浓度（7ng / ml）的尼莫地平给药方法。在新西兰白兔（2.6-3.9kg）中测量尼莫地平的血浆浓度。首先，计算并比较接受口服或皮下尼莫地平（5-15mg / ml）的动物的血浆峰值浓度（C（max）），达到血浆峰值浓度的时间（T（max））和曲线下面积（AUC）参数。公斤）。接下来，在健康动物和具有实验诱导的SAH的动物中皮下注射2.5mg / kg尼莫地平后24小时，测定血浆浓度。与口服尼莫地平相比，皮下注射的C（max），T（max）和AUC参数明显更高，而与剂量无关。在健康动物（12.9 +/- 10.0ng / ml）和接受2.5mg / kg皮下尼莫地平的SAH动物（11.8 +/- 4.6ng / ml）中，在24小时时尼莫地平的平均浓度均> 7ng / ml。在该模型中，尼莫地平的皮下给药方法始终将血浆水平维持在最佳治疗浓度或更高，而口服给药则无法做到。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号