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首页> 外文期刊>Journal of Neuroscience Methods >Electrical stimulation of cortex improves corticospinal tract tracing in rat spinal cord using manganese-enhanced MRI.
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Electrical stimulation of cortex improves corticospinal tract tracing in rat spinal cord using manganese-enhanced MRI.

机译:使用锰增强的MRI,皮质的电刺激改善了大鼠脊髓的皮质脊髓束描迹。

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摘要

Following bilateral injection of manganese (Mn) into the rat's motor cortex, electrical stimulation of the cortex is shown to increase the transport, uptake and accumulation of Mn in the corticospinal tract (CST), as assessed by manganese-enhanced magnetic resonance imaging (MEI). T(1)-weighted gradient echo images were acquired in 3-D and displayed in different orientations to anatomically delineate the CST pathway from cortex to spinal cord (SC) at the thoracic level. T(1)-maps of the SC were produced from spin-echo based image data to demonstrate the distribution of the T(1) properties of the SC tissue and to quantitatively assess the T(1)-change occurring in the CST due to the presence of Mn therein. Implications for improving the tract tracing ability with the proposed in vivo approach and its application to spinal cord injury (SCI) research are discussed in terms of aiding future experimental investigations of neuroplasticity following an injury.
机译:通过锰增强磁共振成像(MEI)评估,在将锰(Mn)双向注入大鼠运动皮层后,皮质的电刺激显示可增加其在皮质脊髓束(CST)中的运输,吸收和积累。 )。 T(1)加权的梯度回波图像以3-D形式获取,并以不同的方向显示,以在解剖学上描述从胸廓到大脑皮层到脊髓(C)的CST通路。从基于自旋回波的图像数据生成SC的T(1)-图,以证明SC组织的T(1)特性的分布并定量评估由于CST而在CST中发生的T(1)-变化。锰的存在。提出的体内方法及其在脊髓损伤(SCI)研究中的应用对改善道追踪能力的意义,是根据对损伤后神经可塑性的未来实验研究进行讨论的。

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