The structure of human apolipoprotein E2, E3 and E4 in solution. 2. Multidomain organization correlates with the stability of apoE structure.

Clement Collin V; Barbier A; Dergunov AD; Visvikis A; Siest G; Desmadril M; Takahashi M; Aggerbeck LP

首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >The structure of human apolipoprotein E2, E3 and E4 in solution. 2. Multidomain organization correlates with the stability of apoE structure.

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The structure of human apolipoprotein E2, E3 and E4 in solution. 2. Multidomain organization correlates with the stability of apoE structure.

机译：溶液中人载脂蛋白E2，E3和E4的结构。 2.多域组织与apoE结构的稳定性有关。

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The stabilities toward thermal and chemical denaturation of three recombinant isoforms of human apolipoprotein E (r-apoE2, r-apoE3 and r-apoE4), human plasma apoE3, the recombinant amino-terminal (NT) and the carboxyl-terminal (CT) domains of plasma apoE3 at pH 7 were studied using near and far ultraviolet circular dichroism (UV CD), fluorescence and size-exclusion chromatography. By far UV CD, thermal unfolding was irreversible for the intact apoE isoforms and consisted of a single transition. The r-apoE3 was found to be less stable as compared to the plasma protein and the stability of recombinant isoforms was r-apoE4

机译：人类载脂蛋白E的三种重组同工型（r-apoE2，r-apoE3和r-apoE4），人血浆apoE3，重组氨基末端（NT）和羧基末端（CT）结构域对热和化学变性的稳定性使用近紫外和远紫外圆二色性（UV CD），荧光和尺寸排阻色谱法研究了pH 7下血浆apoE3的含量。到目前为止，UV CD对完整的apoE亚型而言是不可逆的热展开，它由一个过渡组成。与血浆蛋白相比，发现r-apoE3不稳定，重组同工型的稳定性为r-apoE4

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来源
《Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena》 |2006年第2期|共16页
作者
Clement Collin V; Barbier A; Dergunov AD; Visvikis A; Siest G; Desmadril M; Takahashi M; Aggerbeck LP;
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正文语种 eng
中图分类生物化学;
关键词
apolipoprotein E-3; Assault by stabbing; structure; No treatment required for;

机译：载脂蛋白E-3;刺伤;结构;无需治疗;

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1. The structure of human apolipoprotein E2, E3 and E4 in solution. 2. Multidomain organization correlates with the stability of apoE structure. [J] . Clement Collin V, Barbier A, Dergunov AD, Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena . 2006,第2期

机译：溶液中人载脂蛋白E2，E3和E4的结构。 2.多域组织与apoE结构的稳定性有关。
2. Mass Spectrometry-Based Protein Footprinting Characterizes the Structures of Oligorneric Apolipoprotein E2, E3, and E4 [J] . Gau B, Garai K, Frieden C, Biochemistry . 2011,第38期

机译：基于质谱的蛋白质足迹表征寡聚载脂蛋白E2，E3和E4的结构
3. A 12-week worksite health promotion program reduces cardiovascular risk factors in male workers with the apolipoprotein E2 and apolipoprotein E3 genotypes, but not in apolipoprotein E4 genotype [J] . Cho SW, Kang JY, Park YK, Nutrition Research . 2009,第8期

机译：一项为期12周的工作场所健康促进计划可降低具有载脂蛋白E2和载脂蛋白E3基因型的男性工人的心血管危险因素，但不能降低载脂蛋白E4基因型的男性
4. Essays in economics: 1. Pre-committed government spending and partisan politics. 2. Investment in energy efficiency: Do the characteristics of firms matter? 3. Information processing and organizational structure. [D] . Watkins, William Edward, Jr. 1998

机译：经济学论文：1.预先承诺的政府支出和党派政治。 2.能源效率投资：企业的特征重要吗？ 3.信息处理和组织结构。
5. Mass Spectrometry-based Protein Footprinting Characterizes the Structures of Oligomeric Apolipoprotein E2 E3 and E4 [O] . Brian Gau, Kanchan Garai, Carl Frieden, -1

机译：基于光谱质谱蛋白足迹特征低聚载脂蛋白E2E3和E4的结构
6. Characterization of the Binding of Amyloid-β Peptide to Cell Culture-Derived Native Apolipoprotein E2, E3, and E4 Isoforms and to Isoforms from Human Plasma [O] . Dun-Sheng Yang, Jonathan D. Smith, Zhongmin Zhou, 2002

机译：表征淀粉样蛋白-β肽与细胞培养衍生的天然载体E2，E3和E4同种型的结合和来自人血浆的同种型

The structure of human apolipoprotein E2, E3 and E4 in solution. 2. Multidomain organization correlates with the stability of apoE structure.

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