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首页> 外文期刊>Journal of Neuroscience Methods >A new coordinate system for rodent brain and variability in the brain weights and dimensions of different ages in the naked mole-rat.
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A new coordinate system for rodent brain and variability in the brain weights and dimensions of different ages in the naked mole-rat.

机译：一个新的坐标系统，用于啮齿动物的大脑和裸mole鼠中不同年龄的大脑重量和大小的可变性。

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Traditionally, the skull landmarks, i.e., bregma, lambda, and the interaural line, are the origins of the coordinate system for almost all rodent brain atlases. The disadvantages of using a skull landmark as an origin are: (i) there are differences among individuals in the alignment between the skull and the brain; (ii) the shapes of sutures, on which a skull landmark is determined, are different for different animals; (iii) the skull landmark is not clear for some animals. Recently, the extreme point of the entire brain (the tip of the olfactory bulb) has also been used as the origin for an atlas coordinate system. The accuracy of stereotaxically locating a brain structure depends on the relative distance between the structure and the reference point of the coordinate. The disadvantages of using the brain extreme as an origin are that it is located far from most brain structures and is not readily exposed during most in vivo procedures. To overcome these disadvantages, this paper introduces a new coordinate system for the brain of the naked mole-rat. The origin of this new coordinate system is a landmark directly on the brain: the intersection point of the posterior edges of the two cerebral hemispheres. This new coordinate system is readily applicable to other rodent species and is statistically better than using bragma and lambda as reference points. It is found that the body weight of old naked mole-rats is significantly bigger than that of young animals. However, the old naked mole-rat brain is not significantly heavier than that of young animal. Both brain weight and brain length vary little among animals of different weights. The disadvantages of current definition of "significant" are briefly discussed and a new expression that describes more objectively the result of statistical test is brought up and used.
机译：传统上，头骨地标，即前b，lambda和耳间线，是几乎所有啮齿动物脑图集的坐标系的起源。使用头骨地标作为原点的缺点是：（i）头骨和大脑之间的对齐方式存在个体差异; （ii）确定不同动物头骨的缝合线形状不同; （iii）某些动物的头骨地标不清楚。最近，整个大脑的极点（嗅球的尖端）也已用作图集坐标系的起点。立体定位大脑结构的准确性取决于该结构与坐标参考点之间的相对距离。使用大脑极限作为起源的缺点是它远离大多数大脑结构，并且在大多数体内手术过程中不容易暴露。为了克服这些缺点，本文为裸mole鼠的大脑引入了新的坐标系。这个新坐标系的起源是直接在大脑上的一个里程碑：两个大脑半球后边缘的交点。这个新的坐标系很容易适用于其他啮齿动物物种，并且在统计上比使用bragma和lambda作为参考点更好。发现老裸naked鼠的体重明显大于幼小动物的体重。但是，裸露的mole鼠大脑并不比幼小的动物重。在体重不同的动物中，大脑的重量和大脑的长度变化很小。简要讨论了当前定义“重大”的弊端，并提出并使用了一个更客观地描述统计检验结果的新表达式。

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