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首页> 外文期刊>Journal of Neuroscience Methods >Neural influence on cold induced vasodilatation using a new set-up for bilateral measurement in the rat hind limb.
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Neural influence on cold induced vasodilatation using a new set-up for bilateral measurement in the rat hind limb.

机译：对大鼠后肢进行双侧测量的新装置对神经冷诱导的血管舒张的影响。

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Cold induced vasoconstriction (CIVC) is a way for mammals to reduce heat loss in an effort to maintain body core temperature. As blood flow to a cooled extremity is reduced, the amount of body heat lost at the cooled location is minimised. However, when the extremity temperature gets below a certain threshold, Cold induced vasodilatation (CIVD) occurs, a phenomenon that is believed to reduce the risk of local cold injuries. Many theories explaining the mechanism of the CIVD reaction have been postulated, but no consensus has been found. One of these theories is that the CIVD reaction is controlled neurally. To study the effect of neural influence on the vascularisation and rewarming patterns a new experimental set-up was designed. This set-up is able to measure responses in both hind paws simultaneously, creating the opportunity to study the effect of nerve injury on one limb and use the contralateral limb as a control. Ten rats received a sciatic nerve transection and repair of either the left (n=5) or the right (n=5) hind limb. Measurements were performed, 1 day pre-operatively, directly post-operatively, and at days 1, 7, 14, 21, 35 and 49 post-operatively. Although results are not significant, there is a tendency for the CIVD reaction to be reduced in the nerve injured paw until the nerve is regenerated around day 35. Further investigation of neural influence on the CIVD reaction will be necessary; this set-up may prove to be useful in future experiments to elucidate the mechanism of the CIVD reaction.
机译：冷诱导的血管收缩（CIVC）是哺乳动物减少热量损失以维持体温的一种方法。随着流向冷却的肢体的血流减少，在冷却的部位损失的身体热量最小。但是，当肢体温度低于某个阈值时，就会发生冷诱发的血管扩张（CIVD），这种现象被认为可以减少局部冷伤的风险。已经提出了许多解释CIVD反应机理的理论，但尚未达成共识。这些理论之一是CIVD反应是神经控制的。为了研究神经影响对血管化和复温模式的影响，设计了一种新的实验装置。这种设置能够同时测量两只后爪的反应，从而有机会研究神经损伤对一只肢体的影响，并使用对侧肢体作为对照。十只大鼠接受坐骨神经横断并修复左后肢（n = 5）或右后肢（n = 5）。术前，术后1天，术后1天，术后1、7、14、21、35和49天进行测量。尽管结果并不显着，但在受神经损伤的爪中，直到第三十五天左右神经再生之前，CIVD反应有减少的趋势。有必要进一步研究神经对CIVD反应的影响;此设置可能被证明在阐明CIVD反应机理的未来实验中很有用。

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