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首页> 外文期刊>Journal of Neuroscience Methods >Distinguishing childhood absence epilepsy patients from controls by the analysis of their background brain electrical activity.
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Distinguishing childhood absence epilepsy patients from controls by the analysis of their background brain electrical activity.

机译：通过分析他们的背景脑电活动来区分儿童期失神癫痫患者和对照组。

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摘要

Background electroencephalography (EEG), recorded with scalp electrodes, in children with childhood absence epilepsy (CAE) and control individuals has been analyzed. We considered 5 CAE patients, all right-handed females and aged 6-8 years. The 15 control individuals had the same characteristics of the CAE ones, but presented a normal EEG. The EEG was obtained using bipolar connections from a standard 10-20 electrode placement (Fp1, Fp2, F7, F3, Fz, F4, F8, T3, C3, Cz, C4, T4, T5, P3, Pz, P4, T6, O1 and O2). Recordings were undertaken in the resting state with eyes closed. EEG hallmarks of absence seizure activity are widely accepted, but there is a recognition that the bulk of interictal EEG in CAE appears normal to visual inspection. The functional activity between electrodes was evaluated using a wavelet decomposition in conjunction with the Wootters distance. Then, pairs of electrodes with differentiated behavior between CAE and controls were identified using a test statistic-based feature selection technique. This approach identified clear differences between CAE and healthy control background EEG in the frontocentral electrodes, as measured by Principal Component Analysis. The findings of this pilot study can have strong implications in future clinical practice.
机译：分析了背景性脑电图（EEG），用头皮电极记录了患有儿童缺失型癫痫病（CAE）的儿童和对照组的情况。我们考虑了5位CAE患者，均为右撇子女性，年龄6-8岁。 15名对照个体具有与CAE个体相同的特征，但是表现出正常的EEG。使用双极连接从标准10-20电极位置（Fp1，Fp2，F7，F3，Fz，F4，F8，T3，C3，Cz，C4，T4，T5，P3，Pz，P4，T6， O1和O2）。在静止状态下闭眼进行记录。缺少癫痫发作活动的EEG标志已被广泛接受，但人们已经认识到CAE中大部分的间质EEG看起来对视觉检查是正常的。使用小波分解结合Wootters距离评估电极之间的功能活性。然后，使用基于测试统计的特征选择技术来识别在CAE和控件之间行为不同的电极对。通过主成分分析法，该方法确定了额中央电极中CAE与健康对照背景EEG之间的明显差异。这项初步研究的结果可能对未来的临床实践产生重大影响。

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