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首页> 外文期刊>Journal of Neuroscience Methods >A simple protocol for assessing inter-trial and inter-examiner reliability for two noninvasive measures of limb muscle strength.
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A simple protocol for assessing inter-trial and inter-examiner reliability for two noninvasive measures of limb muscle strength.

机译：一种评估试验间和检查员间可靠性的简单协议，用于两种无创性肢体肌肉力量测量。

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Noninvasive measures of limb muscle strength are quite useful in preclinical translational studies that use mouse models of muscle disease, peripheral nerve disease, and movement disorders. The present study uses a simple protocol for assessing both inter-trial and inter-examiner reliability for two noninvasive methods of assessing limb strength in dystrophic (mdx) and wild type mice. One method, termed the whole body tension (WBT) method or escape test, measures the total phasic pulling tension exerted by the fore- and hindlimbs while a mouse attempts to escape into a darkened tube. Another procedure, termed the four limb wire grid holding test, measures the minimal amount of sustained tension (physical impulse) exerted by the fore- and hindlimbs while the mouse hangs suspended in an upside-down position. A comparison of the two methods revealed significant inter-trial and inter-examiner correlations in each procedure, although the WBT procedure consistently produced higher correlations than the four limb wire grid holding test. Inter-trial reliability for each test was higher than inter-examiner reliability, indicating that each longitudinal series of tests is best performed by a single investigator. The holding test also did not consistently detect differences between wild type and mdx populations at ages greater than 4 months. These results demonstrate the utility of a simple protocol for assessing the reliability of noninvasive tests that measure limb strength, and should be useful in comparing different functional measures in a broad range of translational studies.
机译：在使用肌肉疾病，周围神经疾病和运动障碍的小鼠模型进行的临床前转化研究中，肢体肌肉力量的非侵入性测量非常有用。本研究使用一种简单的协议来评估两次营养不良和野生型小鼠肢体力量的非侵入性方法，以评估试验间和检查者间的可靠性。一种方法称为全身张力（WBT）方法或逃逸测试，用于测量当鼠标试图逃逸到变暗的管中时前肢和后肢施加的总相位拉力。另一种方法称为四肢线栅固定测试，该方法测量了当鼠标悬吊悬吊在上下颠倒位置时，前肢和后肢施加的最小持续张力（身体冲动）。两种方法的比较显示，尽管每个程序都比四肢线栅保持测试始终产生更高的相关性，但在每个程序中，审判间和考官间的相关性均显着。每次测试的审判间可靠性均高于考官间的可靠性，这表明每个纵向试验系列最好由一名研究人员进行。保持测试还不能始终如一地发现大于4个月大的野生型和mdx种群之间的差异。这些结果证明了一种简单的协议可用于评估可测量肢体力量的非侵入性测试的可靠性，并且在广泛的翻译研究中比较不同的功能性指标时应很有用。

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