• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neuroscience Methods >Neuroanatomical correlation of behavioral deficits in the CCI model of TBI.
【24h】

Neuroanatomical correlation of behavioral deficits in the CCI model of TBI.

机译：TBI CCI模型中行为缺陷的神经解剖学相关性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Traumatic brain injury (TBI) is the leading cause of death and disability both in combat and civilian situations with limited treatment options including surgical removal of hematoma, ventricular drainage and use of hyperosmotic agents that restrict secondary injury following TBI. Availability of appropriate model system with full-range characterization of anatomical and behavioral components correlative with brain injury provides a pre-clinical platform to test candidate therapies for clinical translation. Modeling of TBI using controlled cortical impact injury (CCI) is largely considered to be close to clinical TBI and hence CCI models have been widely used in pre-clinical TBI research. Most studies reported so far using CCI models were presented with a limited behavioral characterization and lacked its correlation with the signature histopathology of TBI. Current investigation validated a detailed sensomotor and cognitive behavioral characterization correlative with diffuse axonal injury-the signature histopathology of TBI, in the CCI mouse model of TBI. Present study offers a comprehensively characterized model of TBI that can be used to investigate cellular and molecular mechanisms underlying TBI and to test candidate therapies in developing novel and effective treatments for TBI.
机译：外伤性脑损伤（TBI）是在战斗和平民情况下死亡和残疾的主要原因，其治疗选择有限，包括手术切除血肿，心室引流以及使用高渗透性药物，这些药物可限制TBI继发的继发性损伤。具有与脑损伤相关的解剖和行为成分的全范围表征的适当模型系统的可用性为测试候选疗法的临床翻译提供了临床前平台。使用控制性皮层撞击损伤（CCI）对TBI进行建模在很大程度上被认为与临床TBI接近，因此CCI模型已广泛用于临床前TBI研究。迄今为止，大多数报道使用CCI模型进行的研究仅表现出有限的行为特征，并且与TBI的特征性组织病理学缺乏相关性。目前的研究证实了在弥漫性轴索损伤（TBI的标志性组织病理学）相关的详细的感觉运动和认知行为特征，在TBI的CCI小鼠模型中。本研究提供了全面表征的TBI模型，可用于研究TBI的细胞和分子机制，并在开发新颖有效的TBI治疗方法中测试候选疗法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号