...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neuroscience Methods >Approaches and tools for modeling signaling pathways and calcium dynamics in neurons
【24h】

Approaches and tools for modeling signaling pathways and calcium dynamics in neurons

机译：建模神经元信号传导途径和钙动力学的方法和工具

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Signaling pathways are cascades of intracellular biochemical reactions that are activated by transmembrane receptors, and ultimately lead to transcription in the nucleus. In neurons, both calcium permeable synaptic and ionic channels as well as G protein coupled receptors initiate activation of signaling pathway molecules that interact with electrical activity at multiple spatial and time scales. At small temporal and spatial scales, calcium modifies the properties of ionic channels, whereas at larger temporal and spatial scales, various kinases and phosphatases modify the properties of ionic channels, producing phenomena such as synaptic plasticity and homeostatic plasticity. The elongated structure of neuronal dendrites and the organization of multi-protein complexes by anchoring proteins imply that the spatial dimension must be explicit. Therefore, modeling signaling pathways in neurons utilizes algorithms for both diffusion and reactions. The small size of spines coupled with small concentrations of some molecules implies that some reactions occur stochastically. The need for stochastic simulation of many reaction and diffusion events coupled with the multiple temporal and spatial scales makes modeling of signaling pathways a difficult problem. Several different software programs have achieved different aspects of these capabilities. This review explains some of the mathematical formulas used for modeling reactions and diffusion. In addition, it briefly presents the simulators used for modeling reaction-diffusion systems in neurons, together with scientific problems addressed.
机译：信号传导途径是细胞内生化反应的级联，被跨膜受体激活，并最终导致细胞核转录。在神经元中，钙可渗透的突触通道和离子通道以及G蛋白偶联受体均可启动信号通路分子的激活，这些信号通路分子在多个空间和时间尺度上均与电活动相互作用。在较小的时空尺度上，钙会改变离子通道的特性，而在较大的时空尺度上，各种激酶和磷酸酶会改变离子通道的特性，从而产生诸如突触可塑性和体内稳态可塑性的现象。神经元树突的拉长结构和通过锚定蛋白质组织的多种蛋白质复合物意味着空间维度必须明确。因此，在神经元中对信号传导途径进行建模利用了用于扩散和反应的算法。刺的小尺寸加上一些分子的低浓度意味着某些反应是随机发生的。对许多反应和扩散事件的随机模拟以及多个时空尺度的需求，使得信号通路的建模成为一个难题。几种不同的软件程序已经实现了这些功能的不同方面。这篇评论解释了一些用于模拟反应和扩散的数学公式。此外，它简要介绍了用于对神经元中的反应扩散系统进行建模的模拟器，以及已解决的科学问题。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号