Poisson-Boltzmann model analysis of binding mRNA cap analogues to the translation initiation factor eIF4E.

Szklarczyk O; Zuberek J; Antosiewicz JM

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Poisson-Boltzmann model analysis of binding mRNA cap analogues to the translation initiation factor eIF4E.

机译：结合mRNA帽类似物与翻译起始因子eIF4E的Poisson-Boltzmann模型分析。

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The electrostatic free energy of binding of two analogues of the 5'-mRNA cap, differing in size and electric charge, to the wild type and mutated eukaryotic initiation factor eIF4E was computed using the finite difference solutions to the Poisson-Boltzmann equation. Two definitions of the solute-solvent dielectric boundary were used: van der Waals model, solvent exclusion (SE) model. The computed electrostatic energies were supplemented by estimations of the non polar and entropic contributions. A comparison with experimental data for the investigated systems was done. It appears that the SE model with additional contribution fits experimental findings better than the van der Waals model does.

机译：使用Poisson-Boltzmann方程的有限差分解计算了大小和电荷不同的5'-mRNA帽的两个类似物与野生型和突变的真核起始因子eIF4E结合的静电自由能。使用了溶质-溶剂介电边界的两种定义：van der Waals模型，溶剂排除（SE）模型。通过估计非极性和熵的贡献来补充计算出的静电能。与被调查系统的实验数据进行了比较。似乎具有额外贡献的SE模型比van der Waals模型更适合实验结果。

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《Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena》 |2009年第3期|共8页
作者
Szklarczyk O; Zuberek J; Antosiewicz JM;
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正文语种 eng
中图分类生物化学;生物物理学;
关键词
Models; binding; Initiation Factor; eIF-4E; RNA; Messenger; RNA; 信使;

机译：Models;binding;Initiation Factor;eIF-4E;RNA;Messenger;RNA;信使;

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1. Poisson-Boltzmann model analysis of binding mRNA cap analogues to the translation initiation factor eIF4E. [J] . Szklarczyk O, Zuberek J, Antosiewicz JM Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena . 2009,第1a3期

机译：结合mRNA帽类似物与翻译起始因子eIF4E的Poisson-Boltzmann模型分析。
2. Interaction between yeast eukaryotic initiation factor eIF4E and mRNA 5' cap analogues differs from that for murine eIF4E. [J] . Kiraga Motoszko K, Stepinski J, Niedzwiecka A, Nucleosides, nucleotides and nucleic acids . 2003,第5a8期

机译：酵母真核起始因子eIF4E和mRNA 5'cap类似物之间的相互作用不同于鼠类eIF4E的相互作用。
3. Thermodynamics of 7-methylguanosine cation stacking with tryptophan upon mRNA 5' cap binding to translation factor eIF4E. [J] . Niedzwiecka A, Stepinski J, Balaspiri L, Nucleosides, nucleotides and nucleic acids . 2003,第5a8期

机译：当mRNA 5'帽结合翻译因子eIF4E时，色氨酸堆积的7-甲基鸟苷阳离子的热力学。
4. Feature Mining and Integration for Improving the Prediction Accuracy of Translation Initiation Sites in Eukaryotic mRNAs [C] . Chuang Ma, Dao Zhou, Yanhong Zhou International Conference on Grid and Cooperative Computing; 20061021-23; Hunan(CN) . 2006

机译：特征挖掘和集成，提高真核mRNA翻译起始位点的预测准确性
5. Interactions of eukaryotic translation initiation factors and 3' untranslated region of barley yellow dwarf virus mRNA during protein synthesis: A study of equilibrium binding, kinetics and thermodynamics. [D] . Banerjee, Bidisha. 2014

机译：蛋白质合成过程中大麦黄矮病毒mRNA的真核翻译起始因子和3'非翻译区的相互作用：平衡结合，动力学和热力学的研究。
6. Translation Initiation on mRNAs Bound by Nuclear Cap-binding Protein Complex CBP80/20 Requires Interaction between CBP80/20-dependent Translation Initiation Factor and Eukaryotic Translation Initiation Factor 3g [O] . Junho Choe, Nara Oh, Sungjin Park, 2014

机译：核帽结合蛋白复合物CBP80 / 20结合的mRNA的翻译起始需要CBP80 / 20依赖性翻译起始因子和真核翻译起始因子3g之间的相互作用
7. Poisson-Boltzmann model analysis of binding mRNA cap analogues to the translation initiation factor eIF4E [O] . Szklarczyk, Oliwia, Zuberek, Joanna, Antosiewicz, Jan M. 2009

机译：结合mRNA帽类似物与翻译起始因子eIF4E的Poisson-Boltzmann模型分析

Poisson-Boltzmann model analysis of binding mRNA cap analogues to the translation initiation factor eIF4E.

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