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首页> 外文期刊>Journal of Neuroscience Research >Th17 and Th1 responses directed against the immunizing epitope, as opposed to secondary epitopes, dominate the autoimmune repertoire during relapses of experimental autoimmune encephalomyelitis.
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Th17 and Th1 responses directed against the immunizing epitope, as opposed to secondary epitopes, dominate the autoimmune repertoire during relapses of experimental autoimmune encephalomyelitis.

机译：与继发性表位相反，针对免疫表位的Th17和Th1反应在实验性自身免疫性脑脊髓炎的复发过程中占主导地位。

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摘要

Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease with similarities to multiple sclerosis (MS). It has been suggested that relapses of EAE and MS may be associated with, and even driven by, T cells specific for novel epitopes that are primed during the course of tissue destruction in the target organ or in secondary lymphoid tissues. We show, however, that IFNgamma and IL-17 responses against the immunizing epitope remain dominant through out the course of multiphasic EAE. Furthermore, induction of tolerance against a putative secondary epitope did not prevent clinical relapses.
机译：实验性自身免疫性脑脊髓炎（EAE）是一种炎症性脱髓鞘疾病，与多发性硬化症（MS）相似。已经提出，EAE和MS的复发可能与特异于在目标器官或次级淋巴组织的组织破坏过程中引发的新表位特异的T细胞甚至由其驱动。但是，我们表明，针对免疫表位的IFNgamma和IL-17反应在整个多相EAE过程中仍然占主导地位。此外，诱导对假定的次要表位的耐受性并不能预防临床复发。

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