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首页> 外文期刊>Journal of neurosurgery. >Unruptured intracranial aneurysms in the Familial Intracranial Aneurysm and International Study of Unruptured Intracranial Aneurysms cohorts: Differences in multiplicity and location - Clinical article
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Unruptured intracranial aneurysms in the Familial Intracranial Aneurysm and International Study of Unruptured Intracranial Aneurysms cohorts: Differences in multiplicity and location - Clinical article

机译：家族性颅内动脉瘤中未破裂的颅内动脉瘤和未破裂的颅内动脉瘤的国际研究队列：多样性和位置的差异-临床文章

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Object. Familial predisposition is a recognized nonmodifiable risk factor for the formation and rupture of intracranial aneurysms (IAs). However, data regarding the characteristics of familial IAs are limited. The authors sought to describe familial IAs more fully, and to compare their characteristics with a large cohort of nonfamilial IAs. Methods. The Familial Intracranial Aneurysm (FIA) study is a multicenter international study with the goal of identifying genetic and other risk factors for formation and rupture of IAs in a highly enriched population. The authors compared the FIA study cohort with the International Study of Unruptured Intracranial Aneurysms (ISUIA) cohort with regard to patient demographic data, IA location, and IA multiplicity. To improve comparability, all patients in the ISUIA who had a family history of IAs or subarachnoid hemorrhage were excluded, as well as all patients in both cohorts who had a ruptured IA prior to study entry. Results. Of 983 patients enrolled in the FIA study with definite or probable IAs, 511 met the inclusion criteria for this analysis. Of the 4059 patients in the ISUIA study, 983 had a previous IA rupture and 657 of the remainder had a positive family history, leaving 2419 individuals in the analysis. Multiplicity was more common in the FIA patients (35.6% vs 27.9%, p < 0.001). The FIA patients had a higher proportion of IAs located in the middle cerebral artery (28.6% vs 24.9%), whereas ISUIA patients had a higher proportion of posterior communicating artery IAs (13.7% vs 8.2%, p = 0.016). Conclusions. Heritable structural vulnerability may account for differences in IA multiplicity and location. Important investigations into the underlying genetic mechanisms of IA formation are ongoing.
机译：目的。家族性易感性是颅内动脉瘤（IAs）形成和破裂的公认的不可改变的危险因素。但是，有关家族性IAs特征的数据是有限的。作者试图更全面地描述家族性IA，并将其特征与大量非家族性IA进行比较。方法。家族性颅内动脉瘤（FIA）研究是一项多中心国际研究，旨在确定高致富人群中IA形成和破裂的遗传和其他危险因素。作者将FIA研究队列与国际颅内动脉瘤破裂研究（ISUIA）队列在患者人口统计学数据，IA位置和IA多样性方面进行了比较。为了提高可比性，排除了在ISUIA中具有IA家族史或蛛网膜下腔出血的所有患者，以及两个队列中所有在研究进入之前IA破裂的患者。结果。在FIA研究中招募的983名患者中，IA明确或可能发生IA，其中511名符合该分析的纳入标准。在ISUIA研究的4059位患者中，有983位曾发生过IA破裂，其余657位曾有阳性家族史，剩下2419位患者在分析中。在FIA患者中，多重性更为常见（35.6％比27.9％，p <0.001）。 FIA患者位于大脑中动脉的IAs比例较高（28.6％比24.9％），而ISUIA患者后交通动脉IAs的比例较高（13.7％vs 8.2％，p = 0.016）。结论。可遗传的结构脆弱性可能解释了IA多重性和位置的差异。正在进行有关IA形成的潜在遗传机制的重要研究。

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