• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>CNS drug reviews >Pharmacological actions of NGB 2904, a selective dopamine D3 receptor antagonist, in animal models of drug addiction.
【24h】

Pharmacological actions of NGB 2904, a selective dopamine D3 receptor antagonist, in animal models of drug addiction.

机译：NGB 2904（一种选择性的多巴胺D3受体拮抗剂）在成瘾动物模型中的药理作用。

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

As a continuation of our work with SB-277011A, we have examined the effects of another highly elective dopamine (DA) D3 receptor antagonist, N-(4-[4-{2,3-dichlorophenyl}-1-piperazinyl]butyl)-2-fluorenylcarboxamide (NGB 2904), in animal models of addiction. Our results indicate that by systemic administration, NGB 2904 inhibits intravenous cocaine self-administration maintained under a progressive-ratio (PR) reinforcement schedule, cocaine- or cocaine cue-induced reinstatement of cocaine-seeking behavior, and cocaine- or other addictive drug-enhanced brain stimulation reward (BSR). The action of NGB 2904 on PR cocaine self-administration was long-lasting (1-2 days) after a single injection, supporting its potential use in treatment of cocaine addiction. The effects of NGB 2904 in the BSR paradigm were dose-dependent for both NGB 2904 and cocaine; that is, only lower doses of NGB 2904 were effective, and their putative antiaddiction effect could be overcome by increasing the doses of cocaine or other addictive drugs. A dopamine-dependent mechanism is proposed to explain the effects of NGB 2904 on cocaine's actions in these animal models of drug addiction. The data reviewed in this paper suggest that NGB 2904 or other D3-selective antagonists may have potential in controlling motivation for drug-taking behavior or relapse to drug-seeking behavior, but may have a limited role in antagonizing the acute rewarding effects produced by cocaine or other addictive drugs. In addition, NGB 2904 may also act as a useful tool to study the role of D3 receptors in drug addiction.
机译：作为我们与SB-277011A一起工作的延续，我们检查了另一种高度选择性的多巴胺（DA）D3受体拮抗剂N-（4- [4- {2,3-二氯苯基} -1-哌嗪基]丁基）的作用在成瘾动物模型中，-2-芴基羧酰胺（NGB 2904）。我们的结果表明，通过全身性给药，NGB 2904抑制了静脉内可卡因的自我给药，这种自我给药保持在进行性比例（PR）强化方案，可卡因或可卡因提示诱导的可卡因寻求行为的恢复以及可卡因或其他成瘾药物的作用下增强的脑刺激奖励（BSR）。单次注射后，NGB 2904对PR可卡因自我给药的作用持续很长时间（1-2天），支持其在治疗可卡因成瘾中的潜在用途。 NGB 2904在BSR范式中的作用对NGB 2904和可卡因都是剂量依赖性的。也就是说，只有较低剂量的NGB 2904是有效的，并且可以通过增加可卡因或其他成瘾性药物的剂量来克服其假定的抗成瘾作用。提出了一种多巴胺依赖性机制来解释NGB 2904对这些药物成瘾动物模型中可卡因作用的影响。本文所审查的数据表明，NGB 2904或其他D3选择性拮抗剂可能具有控制吸毒行为或复发成瘾行为的动机，但在拮抗可卡因产生的急性奖励作用方面可能发挥有限的作用。或其他上瘾的药物。此外，NGB 2904还可以用作研究D3受体在成瘾中的作用的有用工具。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号