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首页> 外文期刊>Journal of obstetrics and gynaecology: the journal of the Institute of Obstetrics and Gynaecology >Maternal serum screening for trisomy 21 in women with a false positive result in last pregnancy.
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Maternal serum screening for trisomy 21 in women with a false positive result in last pregnancy.

机译：在上次怀孕中对阳性结果为假阳性的女性进行的21三体性孕妇血清筛查。

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Maternal serum screening for Down syndrome is a common practice in the United Kingdom. A number of factors have been shown to influence the chance of a false positive test result. Analysis of routinely collated information stored on an electronic database in a district general hospital has shown that women with a previous false positive maternal screen are at much greater chance of having a false positive result in their next pregnancy. Overall, there was a fivefold increased risk attributed to biological variation in their serum concentrations of alpha-feto protein (AFP) and human chorionic gonadotrophin (hCG). The potential effect of this was to increase the chance of such women having an unnecessary amniocentesis. Women should be advised of this effect in subsequent pregnancies. Ideally a correction factor should be applied which would reduce the false positive rate without affecting adversely the sensitivity of the test.
机译：唐氏综合症的孕妇血清筛查是英国的一种常见做法。已经显示出许多因素会影响假阳性测试结果的机会。对地区综合医院电子数据库中存储的例行整理信息的分析表明，以前接受过假阳性母亲筛查的妇女在下一次怀孕中出现假阳性结果的可能性要大得多。总体而言，由于血清甲胎蛋白（AFP）和绒毛膜促性腺激素（hCG）的生物学差异而导致的风险增加了五倍。这样做的潜在影响是增加了这类妇女不必要的羊膜穿刺术的机会。在随后的怀孕中应告知妇女这种影响。理想情况下，应使用校正因子，该校正因子将减少假阳性率，而不会不利地影响测试的灵敏度。

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