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首页> 外文期刊>CNS drug reviews >Aripiprazole: a novel atypical antipsychotic drug with a uniquely robust pharmacology.
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Aripiprazole: a novel atypical antipsychotic drug with a uniquely robust pharmacology.

机译：阿立哌唑：一种新型的非典型抗精神病药，具有独特的药理作用。

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Aripiprazole (Abilify(R)) is an atypical antipsychotic drug that has been recently introduced for clinical use in the treatment of schizophrenia. Aripiprazole has a unique pharmacologic profile that includes partial agonism at several G-protein coupled receptors (GPCRs) [especially dopamine (D(2)) and 5-HT(1A)] and antagonistic action at others (especially 5-HT(2A)). Clinical trials indicate that aripiprazole is effective in treating the positive and negative symptoms of schizophrenia. In short-term studies rapid onset of action (within one week) has been demonstrated. Preliminary data indicate that aripiprazole may also be effective in the treatment of manic symptoms of bipolar disorder. At recommended doses, aripiprazole appears to be safe and well tolerated in most adult patients with schizophrenia and schizoaffective disorder. There is only limited information available on the use of aripiprazole in children and adolescents, and pilot data suggest that a revised dosing strategy, based on weight, isindicated in this population. In the long-term studies, the use of aripiprazole was associated with continued efficacy, good compliance and increased time-to-relapse. Aripiprazole represents the first functionally selective atypical antipsychotic drug.
机译：阿立哌唑（Aripify）是一种非典型的抗精神病药，最近已被引入临床用于治疗精神分裂症。阿立哌唑具有独特的药理学特征，包括对几种G蛋白偶联受体（GPCR）[特别是多巴胺（D（2））和5-HT（1A）]的部分激动作用以及对其他受体的拮抗作用（尤其是5-HT（2A）） ）。临床试验表明，阿立哌唑可有效治疗精神分裂症的阳性和阴性症状。在短期研究中，已经证明了起效迅速（一周内）。初步数据表明，阿立哌唑也可能有效治疗躁郁症的躁狂症状。在推荐剂量下，阿立哌唑在大多数患有精神分裂症和精神分裂症的成年患者中似乎是安全的且耐受性良好。关于在儿童和青少年中使用阿立哌唑的信息非常有限，并且初步数据表明，该人群中有根据体重调整剂量的策略。在长期研究中，阿立哌唑的使用与持续的疗效，良好的依从性和增加的复发时间有关。阿立哌唑代表第一种功能选择性非典型抗精神病药。

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