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首页> 外文期刊>Journal of paediatrics and child health >Combined anti-cholinergic and short-acting β-agonist therapy reduces hospital admissions for acute asthma
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Combined anti-cholinergic and short-acting β-agonist therapy reduces hospital admissions for acute asthma

机译：抗胆碱能和短效β-激动剂联合治疗可减少急性哮喘的住院人数

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In patients with moderate or severe asthma, groups treated with combination anticholinergic/SABA therapy had a reduced hospital admission rate compared with groups treated with SABA alone (Fig. 1). The number needed to treat for additional beneficial effect was 16 (95% confidence interval (12 to 29), with an anticipated 27% reduction in the risk of hospital admission. Fifteen trials (n = 2497) that, through stratifying by asthma severity when possible, generated 19 comparisons with no statistical heterogeneity (I2 = 0%) for the primary outcome of reduction in hospital admission. Nine trials were at a low risk of bias and the evidence for hospital admission was high quality. The majority of studies were in pre-school- and school-aged children. Three studies also included a small proportion of infants less than 18 months of age, and there was no evidence that inclusion of these infants with wheezy episodes affected the results. Clinical heterogeneity existed with regard to methods of delivery (majority used nebulisers rather than inhalation device), doses and dosage protocols.
机译：在中度或重度哮喘患者中，与单独使用SABA治疗的组相比，抗胆碱能/ SABA联合治疗组的住院率降低了（图1）。为获得额外的有益效果，需要治疗的人数为16（95％置信区间（12至29），预计入院风险会降低27％。十五项试验（n = 2497），通过对哮喘严重程度进行分层可能产生的19项比较没有统计学差异（I2 = 0％），用于减少入院的主要结果。九项试验的偏倚风险低，入院的证据质量高。大多数研究在学龄前和学龄前儿童三项研究还包括一小部分18个月以下的婴儿，没有证据表明将这些患有喘息发作的婴儿包括在内会影响结果，方法存在临床异质性剂量，剂量和剂量方案（大多数使用雾化器而不是吸入装置）。

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