...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of paediatrics and child health >Transgenerational tobacco smoke exposure and childhood cancer: an observational study.
【24h】

Transgenerational tobacco smoke exposure and childhood cancer: an observational study.

机译：跨代烟草烟雾暴露与儿童期癌症：一项观察性研究。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

AIM: Although tobacco smoke is an established risk factor for adult cancer, studies of the association between parental smoking and childhood cancer have produced inconsistent results. To investigate the transgenerational relationship between pre-natal and post-natal tobacco smoke exposure from the grandmother's pregnancies until after the post-natal period and childhood cancer. METHODS: Exposure to tobacco smoke was recorded for three generations. Data were collected through personal interviews using the paediatric environmental history, and were compared among 128 children with cancer and 128 matched controls. The contingency tables and a logistic multivariable regression model were used to control for possible confounding factors. RESULTS: Smoke exposure during oogenesis (maternal grandmother smokers)--odds ratio (OR) 2.2 (95% confidence interval (CI) 1.1-4.9)--and during the mother' pregnancies--OR 1.8 (95% CI 1.1-3.3)--were significantly associated with an increased risk of childhood cancer. CONCLUSIONS: Tobacco smoke exposure during the grandmother's and mother's pregnancies increase the risk of cancer in the descendants. The results suggest that the biological plausibility of the association between parental smoking and paediatric cancer can be explained by the large latency period of paediatric carcinogenesis.
机译：目的：尽管吸烟是成人癌症的既定危险因素，但有关父母吸烟与儿童癌症之间关系的研究却产生了不一致的结果。调查从祖母怀孕直到产后时期与儿童癌症之间的产前和产后烟草烟雾暴露之间的跨代关系。方法：记录烟草暴露三代。通过使用儿科环境史进行的个人访谈收集了数据，并在128位癌症患儿和128位配对对照中进行了比较。列联表和逻辑多变量回归模型用于控制可能的混杂因素。结果：卵子发生期间（外婆吸烟者）-几率（OR）2.2（95％置信区间（CI）1.1-4.9）-和母亲怀孕期间-烟气暴露OR-- 1.8（95％CI 1.1-3.3） ）-与儿童患癌症的风险增加显着相关。结论：祖母怀孕期间接触烟草烟雾增加了后代患癌的风险。结果表明，父母吸烟与小儿癌症之间关联的生物学合理性可以通过小儿癌变的潜伏期长来解释。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号