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Genital warts and other HPV infections: Established and novel therapies

机译:尖锐湿疣和其他HPV感染:既定又新颖的疗法

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摘要

Wart therapies involve methods of targeted lesion destruction, as well as selective immunologic modification. While there are several therapeutic options, no treatment has been proven to be superior in terms of clinical clearance or recurrence. Controlled trials comparing treatments are currently lacking. Many factors are used in the selection of treatment. Variables that should be taken into account include but are not limited to the morphology of the lesions such as thickness and size, quantity, anatomic location, human papilloma virus (HPV) classification, immunocompromized or immune competent status, as well as the preferences of the patient and the provider, cost and availability. No current treatment completely eradicates the human papillomavirus virus. The availability of vaccinations against HPV infection is contributing to the decreasing incidence of this disease. This contribution highlights conventional therapies, off-label treatment strategies including combination therapies, and prophylaxis for condylomata acuminata.
机译:疣治疗涉及靶向性破坏病变的方法以及选择性的免疫修饰。尽管有多种治疗选择,但没有任何一种方法被证明在临床清除率或复发率方面优于其他治疗方法。目前尚缺乏比较治疗方法的对照试验。选择治疗时会使用许多因素。应考虑的变量包括但不限于病变的形态,例如厚度和大小,数量,解剖位置,人乳头瘤病毒(HPV)分类,免疫功能低下或免疫能力状态,以及对肿瘤的偏好。患者和提供者,成本和可用性。当前的治疗方法还不能完全根除人乳头瘤病毒。针对HPV感染的疫苗接种的可用性正在导致这种疾病的发病率下降。这项贡献突出了常规疗法,包括联合疗法在内的标签外治疗策略以及对尖锐湿疣的预防。

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