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首页> 外文期刊>Journal of Nutritional Science and Vitaminology >Effects of simultaneous dietary fish oil ingestion and sulfur amino Acid supplementation on the lipid metabolism in hepatoma-bearing rats with hyperlipidemia.
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Effects of simultaneous dietary fish oil ingestion and sulfur amino Acid supplementation on the lipid metabolism in hepatoma-bearing rats with hyperlipidemia.

机译：膳食鱼油同时摄入和补充硫氨基酸对高脂血症肝癌大鼠脂质代谢的影响。

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摘要

The effects of simultaneous dietary fish oil ingestion and sulfur amino acid (L-methionine and L-cystine) supplementation on serum lipid concentrations and various parameters related to the lipid metabolism were studied in Donryu rats subcutaneously implanted with an ascites hepatoma cell line, AH109A. A diet containing 10% fish oil was found to reduce serum triglyceride, total cholesterol, (very-low-density lipoprotein plus low-density lipoprotein)-cholesterol, phospholipid and nonesterified fatty acid (NEFA) concentrations in these animals, and dietary supplementation of 1.2% L-methionine and L-cystine also suppressed these serum lipid concentrations. Hepatic fatty acid synthesis and the availability of serum NEFA were decreased, and epididymal adipose tissue lipoprotein lipase (LPL) activity was elevated by dietary fish oil, while LPL activity in various tissues and hepatic fatty acid oxidation were increased by dietary sulfur amino acids, resulting in a reduction in the serum triglyceride concentration by dietary fish oil and sulfur amino acids, respectively. Dietary fish oil suppressed the hepatoma-induced increase in cholesterogenesis in the host liver, and dietary methionine and cystine enhanced bile acid excretion into feces, which were the causes of the hypocholesterolemic effect. In these serum lipid concentrations, there were significant effects of fish oil ingestion and sulfur amino acid supplementation, but no significant interaction between these two factors was seen. These results indicate that dietary fish oil and sulfur amino acid, L-methionine and L-cystine, have hypolipidemic effects in cancer-related hyperlipidemia, and that the effects of these two factors on the decrease in these serum lipid concentrations are additive; these two factors may affect the lipid metabolism via different pathways and mechanisms.
机译：在皮下植入腹水肝癌细胞株AH109A的Donryu大鼠中，研究了同时摄入膳食鱼油和硫氨基酸（L-蛋氨酸和L-胱氨酸）对血清脂质浓度和与脂质代谢相关的各种参数的影响。发现含有10％鱼油的饮食可降低这些动物的血清甘油三酸酯，总胆固醇，（极低密度脂蛋白加低密度脂蛋白）-胆固醇，磷脂和非酯化脂肪酸（NEFA）的浓度，并通过饮食补充1.2％的L-蛋氨酸和L-胱氨酸也抑制了这些血清脂质​​浓度。日粮鱼油降低了肝脏脂肪酸的合成和血清NEFA的利用率，附睾脂肪组织脂蛋白脂酶（LPL）的活性升高，日粮中硫氨基酸增加了各种组织的LPL活性和肝脂肪酸的氧化。分别通过食用鱼油和硫氨基酸降低血清甘油三酯浓度。日粮鱼油抑制了肝癌引起的宿主肝脏胆固醇生成的增加，日粮蛋氨酸和胱氨酸增强了胆汁酸排泄到粪便中，这是降胆固醇作用的原因。在这些血清脂质​​浓度中，鱼油的摄入和硫氨基酸的添加有显着影响，但是这两个因素之间没有显着的相互作用。这些结果表明，膳食鱼油和硫氨基酸L-蛋氨酸和L-胱氨酸在与癌症相关的高脂血症中具有降血脂作用，并且这两个因素对这些血脂浓度降低的影响是累加的。这两个因素可能通过不同的途径和机制影响脂质代谢。

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