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首页> 外文期刊>Journal of Nutritional Science and Vitaminology >Maximum permissive dosage of lactose and lactitol for transitory diarrhea, and utilizable capacity for lactose in Japanese female adults.
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Maximum permissive dosage of lactose and lactitol for transitory diarrhea, and utilizable capacity for lactose in Japanese female adults.

机译：乳糖和乳糖醇对暂时性腹泻的最大允许剂量，以及日本女性成年人的乳糖可利用能力。

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摘要

This study aims to estimate the tolerable lactose intake which can be utilized in the digestion by lactase and in the fermentation by intestinal microbes in Japanese female adults. The first, the maximum permissive dosage of lactose not to induce transitory diarrhea was estimated based on the oral ingestion of lactose at several dose levels in all the subjects, and compared with that of lactitol which is not hydrolyzed by digestive enzymes. A second lactose tolerance test involving 10 g and 30 g of lactose was carried out in 10 subjects showing resistance to diarrhea, and serum glucose and insulin levels and the amount of hydrogen excreted in the breath were measured for comparison with those of glucose and lactitol. Subjects were 43 Japanese female adults (average: age 20.5+/-2.1 y, weight 51.3+/-5.1 kg) who had not been diagnosed as having either hypolactasia or being lactose intolerant. Serum glucose and insulin levels were scarcely elevated following the ingestion of both 10 g and 30 g of lactose, while the amount of hydrogen excreted in the breath was greatly increased following the ingestion of 30 g of lactose, but these levels were less following the ingestion of 10 g of lactose. In contrast, the ingestion of 15 g of glucose significantly increased blood glucose and insulin levels, while no hydrogen was detected in the breath. The maximum permissive dosage of lactose not to induce transitory diarrhea was 0.72 g/kg of body weight and that of lactitol was 0.36 g/kg of body weight in Japanese adults. The digestive capacity of lactase is less than 10 g of lactose by single ingestion, while intestinal microflora are able to ferment approximately 20-30 g of lactose. In addition, the ingestion of more than 10 g of lactose might be contributed as prebiotics.
机译：这项研究的目的是估计日本女性成年女性可耐受的乳糖摄入量，该摄入量可用于乳糖酶消化和肠道微生物发酵。首先，基于在所有受试者中以几种剂量水平口服摄取乳糖，并与未被消化酶水解的乳糖醇相比较，估计了不诱发短暂腹泻的乳糖的最大允许剂量。在表现出腹泻抵抗力的10位受试者中进行了第二次乳糖耐量试验，涉及10 g和30 g乳糖，并测量了血糖，胰岛素水平和呼吸中排出的氢量，以与葡萄糖和乳糖醇进行比较。受试者为43名日本女性成年女性（平均年龄：20.5 +/- 2.1岁，体重51.3 +/- 5.1 kg），他们没有被诊断患有泌乳不足或乳糖不耐症。摄入10 g和30 g乳糖后，血清葡萄糖和胰岛素水平几乎没有升高，而摄入30 g乳糖后，呼吸中排出的氢气量大大增加，但摄入后这些水平降低了10克乳糖相反，摄入15克葡萄糖会显着增加血糖和胰岛素水平，而在呼吸中未检测到氢。在日本成年人中，不诱发短暂性腹泻的乳糖的最大允许剂量为0.72 g / kg体重，乳糖醇的最大允许剂量为0.36 g / kg体重。通过单次摄入，乳糖酶的消化能力小于10 g乳糖，而肠道菌群能够发酵约20-30 g乳糖。此外，摄入10克以上的乳糖可能会作为益生元。

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