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首页> 外文期刊>Journal of Nutritional Science and Vitaminology >Supplementation of Bifidobacterium longum to a high-fat, low-calcium diet lowers cytolytic activity of fecal water in rats injected with 1,2-dimethylhydrazine dihydrochloride.
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Supplementation of Bifidobacterium longum to a high-fat, low-calcium diet lowers cytolytic activity of fecal water in rats injected with 1,2-dimethylhydrazine dihydrochloride.

机译：在高脂肪，低钙饮食中补充长双歧杆菌会降低注射1,2-二甲基肼二盐酸盐的大鼠粪便水的细胞溶解活性。

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摘要

The effects of supplementing Bifidobacterium longum SBT 2928 and Lactobacillus acidophilus SBT 2062 to a high-fat, low-calcium diet on bile acid concentration, fatty acid concentration, cytolytic activity and intestinal alkaline phosphatase (ALP) activity of fecal water in rats injected with and without 1,2-dimethylhydrazine dihydrochloride (DMH) were examined. Male Wistar rats at 8 weeks of age were fed a diet containing 18% coconut oil, 2% corn oil and 0.1% calcium for 15 d. Lyophilized cultures were supplemented to test diets at a concentration of 1%. The feeding of a high-fat, low-calcium diet elevated the bile acid concentration, cytolytic activity and ALP activity of fecal water as compared to the AIN-76A diet, whereas the fatty acid concentration was not changed. None of the cultures had any effect on these parameters. Furthermore, 8 week-old rats were given a single subcutaneous injection of DMH at 40 mg/kg body weight, and fed the same diets for 15 d. The DMH injection had no effect on the bile acid concentration but increased the fatty acid concentration and cytolytic activity of fecal water. In contrast, ALP activity was lower in the DMH-treated rats than in the non-treated rats. The ingestion of B. longum lowered cytolytic activity but had no effect on the bile acids, fatty acids and ALP activity of fecal water. L. acidophilus had no effect on these parameters.
机译：在高脂低钙饮食中补充长双歧杆菌SBT 2928和嗜酸乳杆菌SBT 2062对大肠双歧杆菌注射的大鼠粪便中胆汁酸浓度，脂肪酸浓度，细胞溶解活性和肠碱性磷酸酶（ALP）活性的影响检查了没有1，2-二甲基肼二盐酸盐（DMH）的情况。在8周龄时，给雄性Wistar大鼠喂食含有18％椰子油，2％玉米油和0.1％钙的饮食15天。冻干培养物以1％的浓度补充到测试饮食中。与AIN-76A日粮相比，高脂低钙日粮的饲喂提高了粪便水的胆汁酸浓度，细胞溶解活性和ALP活性，而脂肪酸浓度没有变化。没有文化对这些参数有任何影响。此外，对8周大的大鼠进行了40 mg / kg体重的DMH皮下注射，并以相同的饮食喂养15 d。 DMH注射液对胆汁酸浓度无影响，但增加了粪便水的脂肪酸浓度和细胞溶解活性。相反，在DMH治疗的大鼠中，ALP活性低于未治疗的大鼠。摄入长双歧杆菌降低了细胞溶解活性，但对粪便水的胆汁酸，脂肪酸和ALP活性没有影响。嗜酸乳杆菌对这些参数没有影响。

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