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首页> 外文期刊>Journal of Nutritional Science and Vitaminology >Effects of high magnesium intake on bone mineral status and lipid metabolism in rats.
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Effects of high magnesium intake on bone mineral status and lipid metabolism in rats.

机译：高镁摄入对大鼠骨矿物质状态和脂质代谢的影响。

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摘要

Effects of magnesium (Mg)-intake on mineral levels in bone, blood and various tissues, bone density and plasma lipids were examined in 4-wk-old, female Wistar rats fed diets of five different Mg-contents of 1/10, 1 (standard diet (Mg 47 mg/100 g diet): control group), 2, 5 and 10-fold of the standard content for 4 wk. In rats fed the 1/10-fold Mg diet, the body weight gain declined with a statistical significance compared to control rats, while no significant differences were observed in rats fed on the 2-, 5-, and 10-fold Mg diets. The imbalance of mineral concentrations in the rats fed 1/10 Mg diet was induced, but in the rats fed high Mg diets were not induced except in tibia. Mg concentration in tibia of rats fed the 10-fold Mg diet significantly increased compared to the control group. All groups (1/10-fold, 2-, 5-, and 10-fold Mg groups) showed no significant changes in tibial mineral levels, except Mg in the 10-fold group, compared to the control group. With increase in Mg-intake, decline of plasma lipid parameters such as cholesterol, triglycerides and phospholipids are induced. Based on these results, it was suggested that a higher Mg-intake (around 5-fold of the standard Mg-content) might have a prophylactic potential against the onset of hyperlipidemia and cardiovascular disease by reducing lipid indices, and Mg decline in bone.
机译：在4周龄，饲喂5种不同镁含量（分别为1 / 10、1和1）的Wistar雌性Wistar大鼠中，研究了镁摄入对骨骼，血液和各种组织中矿物质水平，骨密度和血浆脂质的影响。 （标准饮食（Mg 47 mg / 100 g饮食）：对照组），标准含量为2周的2倍，5倍和10倍。在饲喂1/10倍Mg饮食的大鼠中，与对照组相比，体重增加下降具有统计学意义，而在饲喂2倍，5倍和10倍镁饮食的大鼠中没有观察到显着差异。饲喂1/10 Mg饮食的大鼠中矿物质浓度的失衡被诱发，但是饲喂高Mg饮食的大鼠中除胫骨外均未诱导。与对照组相比，饲喂10倍Mg饮食的大鼠胫骨中的Mg浓度显着增加。与对照组相比，所有组（1/10倍，2倍，5倍和10倍镁组）的胫骨矿物质水平均无显着变化，但10倍组中的镁除外。随着镁摄入的增加，引起血浆脂质参数例如胆固醇，甘油三酸酯和磷脂的下降。根据这些结果，建议较高的镁摄入量（约为标准镁含量的5倍）可能通过降低脂质指数和骨骼中的Mg下降来预防高脂血症和心血管疾病的发生。

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