• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Nutritional Science and Vitaminology >Effect of Astaxanthin in Combination with alpha-Tocopherol or Ascorbic Acid against Oxidative Damage in Diabetic ODS Rats.
【24h】

Effect of Astaxanthin in Combination with alpha-Tocopherol or Ascorbic Acid against Oxidative Damage in Diabetic ODS Rats.

机译：虾青素与α-生育酚或抗坏血酸合用对糖尿病ODS大鼠氧化损伤的作用。

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The present study was performed to investigate the effect of astaxanthin in combination with other antioxidants against oxidative damage in streptozotocin (STZ)-induced diabetic Osteogenic Disorder Shionogi (ODS) rats. Diabetic-ODS rats were divided into five groups: control, astaxanthin, ascorbic acid, alpha-tocopherol, and tocotrienol. Each of the four experimental groups was administered a diet containing astaxanthin (0.1 g/kg), in combination with ascorbic acid (3.0 g/kg), alpha-tocopherol (0.1 g/kg), or tocotrienol (0.1 g/kg) for 20 wk. The effects of astaxanthin with other antioxidants on lipid peroxidation, urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) excretion, serum creatinine (Cr) level, creatinine clearance (Ccr), and urinary protein content were assessed. The serum lipid peroxide levels and chemiluminescent (CL) intensity in the liver of the alpha-tocopherol and tocotrienol groups were significantly reduced in comparison to that of the control group. In the alpha-tocopherol group, urinary 8-OHdG excretion, serum Cr level, Ccr, urinary albumin excretion, and urinary protein concentration were significantly decreased as compared with those in the control group. Additionally, the CL intensity in the kidney of the alpha-tocopherol group was significantly lower, but that of the ascorbic acid group was significantly higher than that in the control group. These results indicate that dietary astaxanthin in combination with alpha-tocopherol has an inhibitory effect on oxidative stress. On the other hand, our study suggests that excessive ascorbic acid intake increases lipid peroxidation in diabetic rats.
机译：进行本研究以研究虾青素与其他抗氧化剂联合使用对链脲佐菌素（STZ）诱导的糖尿病成骨性疾病Shioogi（ODS）大鼠氧化损伤的作用。糖尿病-ODS大鼠分为五组：对照组，虾青素，抗坏血酸，α-生育酚和生育三烯酚。四个实验组中的每一个都接受了含有虾青素（0.1 g / kg），抗坏血酸（3.0 g / kg），α-生育酚（0.1 g / kg）或生育三烯酚（0.1 g / kg）的饮食。 20周。评估虾青素与其他抗氧化剂对脂质过氧化，尿中8-羟基-2'-脱氧鸟苷（8-OHdG）排泄，血清肌酐（Cr）水平，肌酐清除率（Ccr）和尿蛋白含量的影响。与对照组相比，α-生育酚和生育三烯酚组的肝脏中的血清脂质过氧化物水平和化学发光（CL）强度显着降低。与对照组相比，α-生育酚组的尿中8-OHdG排泄，血清Cr水平，Ccr，尿白蛋白排泄和尿蛋白浓度显着降低。另外，α-生育酚组的肾脏CL强度明显降低，但抗坏血酸组的肾脏CL强度明显高于对照组。这些结果表明，饮食中虾青素与α-生育酚的结合对氧化应激具有抑制作用。另一方面，我们的研究表明，过量摄入抗坏血酸会增加糖尿病大鼠的脂质过氧化作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号